Biological effects of boron-absorbed C6 glioma cells irradiated by UHZr reactor neutron source

JIANG Xinbiao1 ZHAO Ying1 CAO Ruifeng2 XIAO Yan1  CHEN Wei1 TU Jing1 ZHANG Xiang2  1

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Biological effects of boron-absorbed C6 glioma cells irradiated by UHZr reactor neutron source

更新时间：2021-03-12

- Biological effects of boron-absorbed C6 glioma cells irradiated by UHZr reactor neutron source
- NUCLEAR TECHNIQUES Issue 6, (2005)
- 作者机构：
  
  1. 西北核技术研究所
  2. 第四军医大学西京医院神经外科,西安,710024
  3. ,西安,710032
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目(10375047)
- DOI：
  CLC： R739.4
- Published：01 June 2005
- 稿件说明：
移动端阅览
[1]江新标,赵英,曹锐锋,肖艳,陈伟,屠荆,章翔.铀氢锆堆中子源辐照含硼C6胶质瘤细胞的生物学效应研究[J].核技术,2005(06):458-462.

JIANG Xinbiao1 ZHAO Ying1 CAO Ruifeng2 XIAO Yan1 CHEN Wei1 TU Jing1 ZHANG Xiang2 1. Biological effects of boron-absorbed C6 glioma cells irradiated by UHZr reactor neutron source[J]. Nuclear techniques, 2005, (6): 458-462.
[1]江新标,赵英,曹锐锋,肖艳,陈伟,屠荆,章翔.铀氢锆堆中子源辐照含硼C6胶质瘤细胞的生物学效应研究[J].核技术,2005(06):458-462. DOI：

JIANG Xinbiao1 ZHAO Ying1 CAO Ruifeng2 XIAO Yan1 CHEN Wei1 TU Jing1 ZHANG Xiang2 1. Biological effects of boron-absorbed C6 glioma cells irradiated by UHZr reactor neutron source[J]. Nuclear techniques, 2005, (6): 458-462. DOI：

摘要

利用蒙卡程序MCNP/4B（Monte Carlo N-particle transportcode/4B）设计了C6细胞辐照实验的铀氢锆堆中子源。建立了细胞培养、孵育、L-BPA（L-boron phenylalanine）给药、细胞内宏观硼浓度测定及辐照实验方法

观察了BNCT（Boron neutron capture therapy）辐照实验对体外C6胶质瘤细胞的放射生物学效应

研究了C6细胞BNCT辐照效应与照射剂量之间的关系。试验结果表明

在同等吸收剂量下

BNCT对C6细胞的杀伤作用远远大于γ射线。

Abstract

A neutron source of UHZr reactor for C6 glioma cells irradiation is designed by MCNP/4B code. Methods for cell culture

incubation

L-BPA administration

boron concentration measurement and the irradiation experiment are described. Radiobiological effects of C6 glioma cells in vitro

which are induced by BNCT

and the relations between the biological effect and the irradiation dose are studied. The results demonstrate that the cytocidal effect of the BNCT method is much more remarkable than that of gamma radiotherapy at the same absorbed dose.

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Department of Occupational Radiological Health, Nanjing Municipal Center for Disease Control and Prevention

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新疆大学物理系乌鲁木齐830046

Institute of Low Energy Nuclear Physics, Beijing Normal University

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