The synthesis and analysis of octanoic-1-<sup>13</sup>C acid

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The synthesis and analysis of octanoic-1-¹³C acid

更新时间：2021-03-12

- The synthesis and analysis of octanoic-1-¹³C acid
- NUCLEAR TECHNIQUES Issue 2, (2000)
- 作者机构：
  
  中国科学院上海原子核研究所!上海２０１８００
- 作者简介：
- 基金信息：
- DOI：
  CLC： TL923
- Published：01 February 2000
- 稿件说明：
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[1]王惠琼,赵夏令,唐国忠.辛酸─1—~(13)C的合成与分析[J].核技术,2000(02):136-141.

The synthesis and analysis of octanoic-1-¹³C acid[J]. Nuclear techniques, 2000, (2).
[1]王惠琼,赵夏令,唐国忠.辛酸─1—~(13)C的合成与分析[J].核技术,2000(02):136-141. DOI：

The synthesis and analysis of octanoic-1-¹³C acid[J]. Nuclear techniques, 2000, (2). DOI：

摘要

将以溴代正庚烷为原料合成的格氏试剂溴化正庚基镁与Ｂａ１３ＣＯ３和浓Ｈ２ＳＯ４作用产生的１３ＣＯ２进行羧化反应，通过水解，提纯，制得辛酸─１─１３Ｃ，产率可达９０％─９３％。用薄层层析对其进行了定性分析，利用ＭＳ、ＩＲ、１Ｈ－ＮＭＲ和１３Ｃ－ＮＭＲ对其进行了结构分析和测定１３Ｃ丰度（８９．５％），并按口服药物的质量要求，用ＩＣＰ－ＡＥＳ和ＡＦＳ方法对有关金属元素进行了定量测定。

Abstract

A Grignard reagent prepared from n-heptyl bromide was carbonated with the carbon-1-

C dioxide liberated from barium carbonate-1-

C and concentrated sulfuric acid. The octanoic-1-

C acid was obtained by acidic hydrolysis and purified by extraction. The yield was more than 90%. To analyze the structure and compute the

C abundance of the octanoic-1-

C acid

various analysis of MS

H-NMR and

C-NMR were performed. According to the quality demand of the oral drug

the quantitative measurements of some metallic elements had also been carried out.

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The synthesis and analysis of octanoic-1-13C acid

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Abstract

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The synthesis and analysis of octanoic-1-¹³C acid