Research on labelling chemistry of o-Phenathroline with  <sup>99m</sup>Tc,  <sup>188</sup>Re and stable Re

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Research on labelling chemistry of o-Phenathroline with ^99mTc, ¹⁸⁸Re and stable Re

更新时间：2021-03-12

- Research on labelling chemistry of o-Phenathroline with ^99mTc, ¹⁸⁸Re and stable Re
- NUCLEAR TECHNIQUES Issue 4, (1999)
- 作者机构：
  
  1. 北京市中日友好医院临床医学研究所,北京
  2. ,100875
  3. 北京师范大学,北京
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 April 1999
- 稿件说明：
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[1]包安德,陆丽仪,王学斌,秦林林.邻菲罗啉的~(99m)Tc和~(188)Re标记化学的研究[J].核技术,1999(04):253-256.

Research on labelling chemistry of o-Phenathroline with ^99mTc, ¹⁸⁸Re and stable Re[J]. Nuclear techniques, 1999, (4).
[1]包安德,陆丽仪,王学斌,秦林林.邻菲罗啉的~(99m)Tc和~(188)Re标记化学的研究[J].核技术,1999(04):253-256. DOI：

Research on labelling chemistry of o-Phenathroline with ^99mTc, ¹⁸⁸Re and stable Re[J]. Nuclear techniques, 1999, (4). DOI：

摘要

以SnCl2作还原剂，酒石酸钠钾作中间络合剂，以纸层析法通过三种展开体系，研究了邻菲罗啉（Phed）的99mTc、188Re和稳定铼标记化学，并用离子交换法对99mTc－Phen的表观电荷进行了测定。结果显示，99mTc－Phen标记率可达95％以上；在pH1.0、沸水浴标记条件下，99mTc－Phen为两种或两种以上不同结构标记物的混合物；在pH5.0、室温标记条件下，99mTc－Phen有不同的纸层析行为和表观电荷性质，其稳定性虽较好；但比沸水浴产物差。99mTc－Phen标记物显正电性，但不同标记化合物的表观电荷及其随pH介质的变化有所不同。188Re和稳定铼标记要难于锝标记，在pH1.0、沸水浴条件下，即使大大提高SnCl2的用量，188Re最大标记率仍只有50％左右。

Abstract

With SnCl2 as reductant

tartrate as intermediate ligand

and with the aid of paper chromatography on three kinds of developing agents

the 99mTo

188Re and stable rhenium labelling chemistry with regard to o-phenanthroline (Phen) have been studied. The labelling ratio of 99mTc-Phen can reach to 95%. For different pH values of media and at different labelling temperatures

the 99mTo-Phen products can be different

and they can have different paper chromatographic behavior in some developing agents. The labelling of 188Re and stable rhenium is more difficult than that of 99mTc. Even if large quantity of SnCl2 is used

the labelling ratio of 188Re-phen is singnificantly lower than 99mTo-Phen: the highest labelling ratio is only 50%.

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Research on labelling chemistry of o-Phenathroline with 99mTc, 188Re and stable Re

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摘要

Abstract

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Research on labelling chemistry of o-Phenathroline with ^99mTc, ¹⁸⁸Re and stable Re