The micro-defects of D-RDX were analyzed by small angle X-ray scattering(SAXS).Scale and density of micro-defects in the D-RDX of different the qualities during the crystal growing were investigated.The results show that the larger D-RDX crystals have less micro-defect density and better crystal quality.Micro-defects with orientated distributions in the D-RDX indicated anisotropic microstructure in D-RDX.