Particle size distribution of iron nanomaterials in biological medium by SR-SAXS method

WANG Yun1; 2 JING Long1 FENG Weiyue1 WANG Bing1 WANG Huajiang1; 2 ZHU Motao1; 2 WANG Meng1 OUYANG Hong1 ZHAO Yuliang1 CHAI Zhifang1 WU Zhonghua31

doi:null

您当前的位置：

首页 >

文章列表页 >

Particle size distribution of iron nanomaterials in biological medium by SR-SAXS method

更新时间：2021-03-12

- Particle size distribution of iron nanomaterials in biological medium by SR-SAXS method
- NUCLEAR TECHNIQUES Vol. 32, Issue 1, (2009)
- 作者机构：
  
  1. 中国科学院高能物理研究所核分析技术重点实验室及纳米生物效应与安全性联合实验室
  2. 中国科学院研究生院
  3. 中国科学院高能物理研究所同步辐射国家实验室
- 作者简介：
- 基金信息：
  
  国家重大基础研究专项基金(2006CB705605);中国科学院和国家自然科学基金(10490180,20475055,10675139)资助
- DOI：
  CLC： TB383.1
- Published：01 January 2009
- 稿件说明：
移动端阅览
[1]王云,荆隆,丰伟悦,汪冰,王华建,朱墨桃,王萌,欧阳宏,赵宇亮,柴之芳,吴忠华.同步辐射X射线小角散射法研究纳米铁材料在生物介质中的粒度分布[J].核技术,2009,32(01):1-5.

WANG Yun1, 2 JING Long1 FENG Weiyue1 WANG Bing1 WANG Huajiang1, 2 ZHU Motao1, et al. Particle size distribution of iron nanomaterials in biological medium by SR-SAXS method[J]. Nuclear techniques, 2009, 32(1): 1-5.
[1]王云,荆隆,丰伟悦,汪冰,王华建,朱墨桃,王萌,欧阳宏,赵宇亮,柴之芳,吴忠华.同步辐射X射线小角散射法研究纳米铁材料在生物介质中的粒度分布[J].核技术,2009,32(01):1-5. DOI：

WANG Yun1, 2 JING Long1 FENG Weiyue1 WANG Bing1 WANG Huajiang1, 2 ZHU Motao1, et al. Particle size distribution of iron nanomaterials in biological medium by SR-SAXS method[J]. Nuclear techniques, 2009, 32(1): 1-5. DOI：

摘要

在研究纳米材料的生物效应时

首先需要对纳米材料在生物介质中的物理化学性质进行全面详细的表征。受生物介质中高蛋白浓度和高离子强度的影响

纳米颗粒在生物介质中极易团聚

对纳米颗粒在生物分散体系中的粒度表征十分困难。本实验采用同步辐射X射线小角散射法（SR-SAXS）研究纳米Fe、Fe2O3和Fe3O4颗粒及其在磷酸盐缓冲液（PBS）、DMEM培养基分散体系中的粒度分布

并与TEM结果进行比较。结果显示SR-SAXS可准确测试纳米Fe、Fe2O3和Fe3O4颗粒的粒度分布

且不受分散体系和分散浓度的影响。表明SR-SAXS可很好地应用于测试稳定性较差的非均匀分散体系中纳米颗粒的粒度分析。

Abstract

A better understanding of biological effects of nanomaterials in organisms requests knowledge of the physicochemical properties of nanomaterials in biological systems. Affected by high concentration salts and proteins in biological medium

nanoparticles are much easy to agglomerate

hence the difficulties in characterizing size distribution of the nanomaterials in biological medium. In this work

synchrotron radiation small angle X-ray scattering (SR-SAXS) was used to determine size distributions of Fe

Fe2O3 and Fe3O4 nanoparticles of various concentrations in PBS and DMEM culture medium. The results show that size distributions of the nanomaterials could perfectly analyzed by SR-SAXS. The SR-SAXS data were not affected by the particle content and types of the dispersion medium. It is concluded that SR-SAXS can be used for size measurement of nanomaterials in unstable dispersion systems.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Concept design of small angle X-ray scattering beamline and station in SSRF

Related Author

LIU Yi

Related Institution

Shanghai Institute of Applied Physics, the Chinese Academy of Sciences

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881163 Visits Today：690

⁰