Relationship between P53 and bystander effect Induced by radiated hepatoma cells

ZHAO Meijia SHEN Bo YUAN Dexiao CHENG Honghong SHAO Chunlin

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Relationship between P53 and bystander effect Induced by radiated hepatoma cells

更新时间：2021-03-12

- Relationship between P53 and bystander effect Induced by radiated hepatoma cells
- NUCLEAR TECHNIQUES Vol. 32, Issue 6, (2009)
- 作者机构：
  
  复旦大学放射医学研究所
- 作者简介：
- 基金信息：
  
  国家自然科学基金(30670629,30770644);教育部新世纪优秀人才支持计划(NCET-06-0365);上海市浦江人才计划(06PJ14012)项目资助
- DOI：
  CLC： R735.7
- Published：01 June 2009
- 稿件说明：
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[1]赵镁嘉,沈波,袁德晓,陈红红,邵春林.受辐射肝癌细胞所诱导旁效应与p53的关系[J].核技术,2009,32(06):469-472.

ZHAO Meijia SHEN Bo YUAN Dexiao CHENG Honghong SHAO Chunlin. Relationship between P53 and bystander effect Induced by radiated hepatoma cells[J]. Nuclear techniques, 2009, 32(6): 469-472.
[1]赵镁嘉,沈波,袁德晓,陈红红,邵春林.受辐射肝癌细胞所诱导旁效应与p53的关系[J].核技术,2009,32(06):469-472. DOI：

ZHAO Meijia SHEN Bo YUAN Dexiao CHENG Honghong SHAO Chunlin. Relationship between P53 and bystander effect Induced by radiated hepatoma cells[J]. Nuclear techniques, 2009, 32(6): 469-472. DOI：

摘要

通过检测受照射细胞及与其共培养旁细胞的损伤情况及p53抑制剂对其的影响

研究了肝癌细胞辐射敏感性及辐射诱导的旁效应与p53的关系。发现肝癌细胞的辐射敏感性与p53密切相关:野生型p53辐射敏感性最高

突变型的次之

缺失型的敏感性最低。同时

辐射诱导的旁效应与p53状态亦密切相关

仅野生型p53肝癌细胞（HepG2）对旁细胞（Chang氏肝细胞）具有旁效应

且未受照射旁细胞中产生的微核具有明显的剂量效应和时间效应;而突变型（PLC）和缺失型（Hep3B）的肝癌细胞几乎不能诱导辐射旁效应的产生。另外

p53抑制剂可显著抑制辐射旁效应的产生。

Abstract

The role of p53 in bystander responses on normal liver cells were investigated by co-culturing irradiated hepatoma cells with non-irradiated bystander Chang liver cells.It was found that radiosensitivity of the hepatoma cells was relative to p53.HepG2 cells with wtp53 had the highest radiosensitivity followed by PLC/PRF/5 cells with mtp53 and Hep3B cells with null-p53.The induction of bystander micronucleus(MN) was observed only in the Chang liver cells that had been co-cultured with HepG2 cells but not co-cultured with PLC/PRF/5 or Hep3B.Also

this bystander MN was relative to the irradiation dose and the cell co-culture rime.When the hepatoma cells were treated with pifithrin-α

a p53 inhibitor

their radiosensitivities were reduced

and the bystander effect was diminished.The results indicate that p53 could regulate not only the radiosensitivity but also the bystander response.

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