Radiation synthesis of temperature-sensitive β-cyclodextrin-Grafted PEG/poly(N-isopropylacrylamide) hydrogels for drug delivery

LIN Han CHEN Jie QI Haoling SHEN Li FAN Jinchen CAO Fangqi

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Radiation synthesis of temperature-sensitive β-cyclodextrin-Grafted PEG/poly(N-isopropylacrylamide) hydrogels for drug delivery

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- Radiation synthesis of temperature-sensitive β-cyclodextrin-Grafted PEG/poly(N-isopropylacrylamide) hydrogels for drug delivery
- NUCLEAR TECHNIQUES Vol. 32, Issue 5, (2009)
- 作者机构：
  
  上海大学环境与化学工程学院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R94
- Published：01 May 2009
- 稿件说明：
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[1]林汉,陈捷,戚昊玲,沈丽,范金辰,曹芳琦.PEG-β-CD/NIPAAm水凝胶的辐射制备及药物控制释放研究[J].核技术,2009,32(05):375-378.

LIN Han CHEN Jie QI Haoling SHEN Li FAN Jinchen CAO Fangqi. Radiation synthesis of temperature-sensitive β-cyclodextrin-Grafted PEG/poly(N-isopropylacrylamide) hydrogels for drug delivery[J]. Nuclear techniques, 2009, 32(5): 375-378.
[1]林汉,陈捷,戚昊玲,沈丽,范金辰,曹芳琦.PEG-β-CD/NIPAAm水凝胶的辐射制备及药物控制释放研究[J].核技术,2009,32(05):375-378. DOI：

LIN Han CHEN Jie QI Haoling SHEN Li FAN Jinchen CAO Fangqi. Radiation synthesis of temperature-sensitive β-cyclodextrin-Grafted PEG/poly(N-isopropylacrylamide) hydrogels for drug delivery[J]. Nuclear techniques, 2009, 32(5): 375-378. DOI：

摘要

采用聚乙二醇缩水甘油酯（PEGDE）对β-环糊精（β-CD）进行改性

合成了新型水溶性的β-环糊精大分子单体（PEG-β-CD）。以电子束为辐射源对PEG-β-CD和N-异丙基丙烯酰胺（NIPAAm）混合物水溶液进行辐照

制备了poly（PEG-β-CD/NIPAAm）水凝胶。与PNIPAAm相比

poly（PEG-β-CD/NIPAAm）水凝胶在室温下具有更高的溶胀率以及在温度升到LCST（Lower Critical Solution Temperature

32℃）后具有更快的收缩响应性。以5-氟尿嘧啶（5-FU）作为模型药物的体外释放实验表明

poly（PEG-β-CD/NIPAAm）水凝胶比PNIPAAm的释放时间有所延长。此现象可能归因于环糊精分子与药物分子形成了包合物。

Abstract

In this paper

β-cyclodextrin(β-CD)-based water-soluble macromonomer(PEG-β-CD) was synthesized by reaction of β-CD with poly(ethylene glycol) diglycidyl ether(PEGDE).A novel temperature-sensitive hydrogel composed of PEG-β-CD and poly(N-isopropylacrylamide)(PNIPAAm) was prepared by E-beam irradiation.Compared with the normal PNIPAAm hydrogel

the obtained hydrogel had a high swelling ratio at room temperature and exhibited faster shrinking kinetics at temperature close to the lower critical solution temperature(LCST).5-fluorouracil(5-FU) was chosen as a model drug loaded into the hydrogels

and the release results showed the β-cyclodextrin-containing hydrogels prolonged the release time.

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Related Institution

School of Radiation Medicine and Protection, Medical College of Soochow University, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection

上海大学环境与化学工程学院

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