ICP-MS analysis for TiO<sub>2</sub> distribution in mice injected with 3 nm TiO<sub>2</sub> particles

YIN Jilei1; 2 LI Yufeng3 KANG Cheng3 ZHU Ying1 LI Yulan1 LI Wenxin1 GONG Qianfeng2 HUANG Qing1 LI Qingnuan1 1

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ICP-MS analysis for TiO₂ distribution in mice injected with 3 nm TiO₂ particles

更新时间：2021-03-12

- ICP-MS analysis for TiO₂ distribution in mice injected with 3 nm TiO₂ particles
- NUCLEAR TECHNIQUES Vol. 32, Issue 4, (2009)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所
  2. 江西中医学院
  3. 中国科学院研究生院
- 作者简介：
- 基金信息：
  
  国家重大基础研究专项基金(2006CB705600);国家自然科学基金(10775169);上海市纳米专项(0752nm021)资助
- DOI：
  CLC： Q504
- Published：01 April 2009
- 稿件说明：
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[1]殷吉磊,李玉峰,康成,诸颖,李玉兰,李文新,龚千锋,黄庆,李晴暖.ICP-MS法研究3nm TiO_2的小鼠体内分布[J].核技术,2009,32(04):313-316.

YIN Jilei1, 2 LI Yufeng3 KANG Cheng3 ZHU Ying1 LI Yulan1 LI Wenxin1 GONG Qianfeng2 HUANG Qing1 LI Qingnuan1 1. ICP-MS analysis for TiO₂ distribution in mice injected with 3 nm TiO₂ particles[J]. Nuclear techniques, 2009, 32(4): 313-316.
[1]殷吉磊,李玉峰,康成,诸颖,李玉兰,李文新,龚千锋,黄庆,李晴暖.ICP-MS法研究3nm TiO_2的小鼠体内分布[J].核技术,2009,32(04):313-316. DOI：

YIN Jilei1, 2 LI Yufeng3 KANG Cheng3 ZHU Ying1 LI Yulan1 LI Wenxin1 GONG Qianfeng2 HUANG Qing1 LI Qingnuan1 1. ICP-MS analysis for TiO₂ distribution in mice injected with 3 nm TiO₂ particles[J]. Nuclear techniques, 2009, 32(4): 313-316. DOI：

摘要

采用溶胶-凝胶法合成粒径为3nm的TiO2颗粒

通过尾静脉注射到小鼠体内

在不同时间点剖取重要脏器

并用电感耦合等离子体-质谱法（ICP-MS）测量各个器官内TiO2的含量。结果显示

尾静脉注射进入小鼠体内的TiO2

很快随血流分布到全身各脏器

滞留在体内的TiO2主要集中在肺、肝、脾三脏

每克组织的摄取量（%ID/g）分别在6h、1h、1h达到最大值141.73%、25.55%、18.07%。实验还发现

对照组小鼠脑中Ti的含量高于血液

静脉注射3nmTiO2后

小鼠脑中Ti的含量显著增加

在实验的各个时间点（除0.5h）

实验组小鼠脑中Ti的含量都比血液高。结果表明纳米TiO2颗粒的脑毒性研究可能成为其生物效应研究的重点。

Abstract

In this work

TiO2 nanoparticles of 3 nm in size were synthesized by sol-gel technique and injected intravenously into mice.The organs were collected at 0.5

24 and 48 h after injection.Ti content in the organs was detected by inductively coupled plasma mass spectrometry(ICP-MS).The results indicated that injected TiO2 nanoparticles were translocated into the organs via bloodstream immediately after injection

and deposited mostly in lung

liver and spleen.The TiO2 uptake(%ID/g) in the three organs reached the peak value of 141.73%

25.55%

and 18.07% at 6 h

1 h and 1 h after injection

respectively.The results also showed that there was significant amount of Ti in the brains of the control

and the brain Ti content increased markedly after injection.At 1

24 and 48 h after injection the brain Ti content was higher than that in blood.The experiment indicated that its toxicity on brain would be the emphasis of biological impact study of nano TiO2.

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ICP-MS analysis for TiO2 distribution in mice injected with 3 nm TiO2 particles

DOI：

摘要

Abstract

关键词

Keywords

references

ICP-MS analysis for TiO₂ distribution in mice injected with 3 nm TiO₂ particles