Characteristic images of 99mTc-MDP bone scintigraphy in patients with metabolic bone diseases (MBD) were analyzed and compared

in an attempt to improve the capability of differential diagnosis in this aspect.A total of 142 cases

clinically confirmed as (MBD)

were categorized into six groups: hyperparathyroidism (117)

renal osteodystrophy (4)

Paget’s disease (16)

hypophosphatemic osteomalacia (2)

Albers-Schonberg disease ( 2)

and Brittle bone disease (1).They were diagnosed clinically or pathologically

and scanned with 99mTc-MDP bone scintegraphy

from which the 142 MBD cases were classified into 4 types.The cases of Type I had increased amount of 99mTc-MDP uptake in whole body bones

including hyperparathyroidism

Albers-Schonberg disease

brittle bone disease and renal osteodystrophy.The cases of Type II had high uptake of 99mTc-MDP in local region of bones

including paget’s disease

hypophosphatemic osteomalacia and hyperparathyroidism.A Type I case with pathological fracture or secondary osteopathy was classified as Type III.Type IV cases were in early stage of hyperparathyroidism

with normal bone scan image.Analysis of the characteristics of 99mTc-MDP bone scintigraphic findings (locations

morphology and intensities) in patients with MBD may be helpful in the differential diagnosis of MBD

in association with the patient’s history and X-ray data altogether.