Preparation of <sup>131</sup>  I-epidepride and biodistribution study in SD rats

YANG Min  1  HU Mingyang  1  PEI Zhuguo  2  WANG Bocheng  1  ZHOU Xingqin  1    FEN Yingying  1  YU Yanhua  1  CHEN Zhiming  1  WANG Yang  1  1

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Preparation of ¹³¹ I-epidepride and biodistribution study in SD rats

更新时间：2021-03-12

- Preparation of ¹³¹ I-epidepride and biodistribution study in SD rats
- NUCLEAR TECHNIQUES Issue 5, (2002)
- 作者机构：
  
  1. 江苏省原子医学研究所
  2. 中国医科大学第二临床学院核医学科
  3. 江苏省原子医学研究所核医学国家重点实验室无锡,214063
  4. 核医学国家重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817.1
- Published：01 May 2002
- 稿件说明：
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[1]杨敏,胡名扬,裴著果,王博诚,周杏琴,冯瑛瑛,虞燕华,陈志明,汪洋.~(131)I-epidepride的制备与SD大鼠体内分布特性研究[J].核技术,2002(05):335-340.

YANG Min 1 HU Mingyang 1 PEI Zhuguo 2 WANG Bocheng 1 ZHOU Xingqin 1 FEN Yingying 1 YU Yanhua 1 CHEN Zhiming 1 WANG Yang 1 1. Preparation of ¹³¹ I-epidepride and biodistribution study in SD rats[J]. Nuclear techniques, 2002, (5): 335-340.
[1]杨敏,胡名扬,裴著果,王博诚,周杏琴,冯瑛瑛,虞燕华,陈志明,汪洋.~(131)I-epidepride的制备与SD大鼠体内分布特性研究[J].核技术,2002(05):335-340. DOI：

YANG Min 1 HU Mingyang 1 PEI Zhuguo 2 WANG Bocheng 1 ZHOU Xingqin 1 FEN Yingying 1 YU Yanhua 1 CHEN Zhiming 1 WANG Yang 1 1. Preparation of ¹³¹ I-epidepride and biodistribution study in SD rats[J]. Nuclear techniques, 2002, (5): 335-340. DOI：

摘要

采用双氧水标记法和氯胺 -T法进行13 1I -epidepride标记

考察标记物的纯度及稳定性

并进行SD大鼠体内分布特性研究。实验结果表明

双氧水法和氯胺 -T法标记率分别为 97.4 %和 5 2 .9%。标记物的生理盐水溶液室温放置 4h

放化纯大于 90 %。大鼠静脉注射13 1I -epide pride的生理盐水溶液后

纹状体与小脑比值在注射后 32 0min时高达 2 37:1。13 1I -epidepride进入血液后很快被组织摄取

其中以肺的早期摄取最高（2 .11± 1.0 5 ） %ID·g- 1

各脏器的清除均较快（T1/2 <4h）

甲状腺的摄取率随时间的延长而增加。

Abstract

The purpose of this article is to study the preparation and biodistribution in animals of dopamine D2 receptor ligand 131 I-epidepride. Epidepride was 131 I radioiodinated with hydroperoxide or chloramine-T method. The purity and stability of 131 I-epidepride were studied by HPLC and TLC

the dynamic distribution in brain and critical organs of SD rats were studied. The radiolabelling yields of 131 I-epidepride were 97.4% and 52.9% respectively. With no more purification

the hydroperoxide method is better than the chloramine-T method. After 4 hours in room temperature

the radiochemical purity of 131 I-epidepride was still over 90%. The striatum uptake was good

the striatum/cerebellum ratio reached 237:1 at 320min. Among the critical organs

lung had the first and the highest uptake. All organs had quick clearance ( T 1/2 <4h). The radioactivity in thyroid increased with time. The results show that 131 I-epidepride has a high striatum uptake and a high striatum/cerebellum ratio. 131 I-epidepride is a good dopamine D2 receptor agent

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Preparation of 131 I-epidepride and biodistribution study in SD rats

DOI：

摘要

Abstract

关键词

Keywords

references

Preparation of ¹³¹ I-epidepride and biodistribution study in SD rats