Preparation of Tc-carbonyl complexes of tryptophan and histidine   and biodistribution in mice bearing S180 tumor

CHU Taiwei  XIE Jinglin  WANG Xiangyun

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Preparation of Tc-carbonyl complexes of tryptophan and histidine and biodistribution in mice bearing S180 tumor

更新时间：2021-03-12

- Preparation of Tc-carbonyl complexes of tryptophan and histidine and biodistribution in mice bearing S180 tumor
- NUCLEAR TECHNIQUES Issue 5, (2002)
- 作者机构：
  
  1. 北京大学化学与分子工程学院应用化学系
  2. 北京大学化学与分子工程学院应用化学系,北京,100871
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助 (2 90 310 2 0 - 0 2 )项目
- DOI：
  CLC： R817.1
- Published：01 May 2002
- 稿件说明：
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[1]褚泰伟,谢景林,王祥云.色氨酸、组氨酸羰基锝配合物的制备及其在荷S180瘤小鼠体内的分布[J].核技术,2002(05):361-366.

CHU Taiwei XIE Jinglin WANG Xiangyun. Preparation of Tc-carbonyl complexes of tryptophan and histidine and biodistribution in mice bearing S180 tumor[J]. Nuclear techniques, 2002, (5): 361-366.
[1]褚泰伟,谢景林,王祥云.色氨酸、组氨酸羰基锝配合物的制备及其在荷S180瘤小鼠体内的分布[J].核技术,2002(05):361-366. DOI：

CHU Taiwei XIE Jinglin WANG Xiangyun. Preparation of Tc-carbonyl complexes of tryptophan and histidine and biodistribution in mice bearing S180 tumor[J]. Nuclear techniques, 2002, (5): 361-366. DOI：

摘要

采用两步法合成了色氨酸及组氨酸的羰基锝配合物。纸上电泳结果表明

在pH为 4 .7、7.4和 9.2三种缓冲体系中配合物不带电荷。从实验结果推测了其可能的结构。在荷肉瘤S180的小鼠体内分布实验表明

组氨酸羰基锝配合物在体内稳定

清除速率也较快

在肿瘤中有较高的摄取

肿瘤 /肌肉达到 3— 4。而色氨酸的羰基锝配合物在体内不稳定

各组织和器官内滞留时间较长、摄取较高

肿瘤中也有一定的摄取

肿瘤 /肌肉为 2— 3

但其效果远不如组氨酸羰基锝配合物。讨论了利用羰基锝标记多肽和蛋白质的途径

Abstract

The Tc-carbonyl complexes of tryptophan and histidine were synthesized by two-step method. The yielded complexes were found by paper electrophoresis to be electrically neutral in three buffer solutions (pH=4.7

7.4

9.2). Their possible structures were postulated based on ab initio MO calculations. The biodistribution in mice bearing S180 tumor demonstrated that the Tc-carbonyl complex of histidine showed good stability in vivo and quick clearance

selectively accumulated in tumor. The tumor/muscle ratio attained 3 to 4. However

the complex of tryptophan showed poor stability in vivo and slow clearance

and retained for a long time in organs and tissues. It also accumulated in tumor to some extent. The tumor/muscle ratio attained 2 to 3. The labeling of proteins and polypeptides with the Tc(I)-carbonyl complex was also discussed.

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