Preliminary study on application of synchrotron radiation imaging to tumor angiogenesis

GU Xiang1 LIU Xiaoxia1 SUN Jianqi2 XIAO Tiqiao3 LIU Ping2 1

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Preliminary study on application of synchrotron radiation imaging to tumor angiogenesis

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- Preliminary study on application of synchrotron radiation imaging to tumor angiogenesis
- NUCLEAR TECHNIQUES Vol. 32, Issue 7, (2009)
- 作者机构：
  
  1. 上海交通大学生命科学技术学院生物医学工程系
  2. 上海交通大学Med-X研究院
  3. 中国科学院上海应用物理研究所
- 作者简介：
- 基金信息：
  
  国家自然科学基金(50725622,10705020);上海市重点项目(08JC1411900)资助
- DOI：
  CLC： R73-3
- Published：01 July 2009
- 稿件说明：
移动端阅览
[1]顾翔,刘晓霞,孙建奇,肖体乔,刘苹.同步辐射成像技术应用于肿瘤新生血管的实验初探[J].核技术,2009,32(07):487-491.

GU Xiang1 LIU Xiaoxia1 SUN Jianqi2 XIAO Tiqiao3 LIU Ping2 1. Preliminary study on application of synchrotron radiation imaging to tumor angiogenesis[J]. Nuclear techniques, 2009, 32(7): 487-491.
[1]顾翔,刘晓霞,孙建奇,肖体乔,刘苹.同步辐射成像技术应用于肿瘤新生血管的实验初探[J].核技术,2009,32(07):487-491. DOI：

GU Xiang1 LIU Xiaoxia1 SUN Jianqi2 XIAO Tiqiao3 LIU Ping2 1. Preliminary study on application of synchrotron radiation imaging to tumor angiogenesis[J]. Nuclear techniques, 2009, 32(7): 487-491. DOI：

摘要

肿瘤新生血管对肿瘤的生长、转移有重要作用

但目前传统影像技术只能分辨直径大于200μm的血管。同步辐射相衬成像技术对生物软组织如血管、肿瘤等成像有巨大优势

空间分辨率可达1μm。本研究用上海光源（SSRF）X射线成像与生物医学应用光束线站

不使用造影剂

对不同时期的裸鼠脊背皮翼4T1乳腺癌视窗模型内的肿瘤新生血管相衬成像

观察到密集、不规则、细小弯曲的肿瘤新生血管

能分辨的最小血管直径20-30μm。

Abstract

Angiogenesis plays an important role in tumor growth and metastasis.However

only vessels lager than 200 μm in diameter can be observed using conventional medical image.Synchrotron radiation(SR) phase contrast imaging

with a spatial resolution being as high as 1 μm

has great advantages in imaging soft tissue structure

such as blood vessels and tumors.The morphology of tumor angiogenesis at different stages in the 4T1 nude mice tumor window model was firstly studied without contrast agent using the SR phase contrast imaging at SSRF X-ray imaging and biomedical application beamline.The results showed dense

irregular and tortuous tumor angiogenesis with the smallest vessels of 20-30 μm in diameter.

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