Nude mice bearing human B cell lymphoma were divided into four groups:control

Fab antibody

single injection and duplication injection. Radioimmunoimages were taken after injection with 131I-labeled Fab antibody through tail vein. The cancer-bearing mice were detected by MRI combined with microscopy coil every 5 days

and tumor sizes were measured. On the 25th day after injection

the tumors were taken out for pathology and apoptosis analysis by flow cytometry (FCM) and TEM

respectively. The results of ECT showed that radioactive nuclide enriched in the area of the tumor obviously at 8 hour after injection

and the mass could be displayed clearly. The growth suppression effect could be displayed in 5 days in Fab antibody group and the apoptotic rate was (2.48±0.6)%. The growth suppression effect was obvious in the prophase in single injection group

and the plateau phase could be seen in the tumor growth curve

with the apoptotic rate of (10.67±1.6)%. The growth suppression effect was more obvious in duplication injection group and the local tissues of tumor necrosed and fallen off

with the apoptotic rate of (14.00±1.9)%. The pathologic results showed tissue necroses in both single group and duplication injection group. The MRI image conformed to the results of pathology

and could provide accurate pathology information by contrast medium enhancement. 131I labeled Fab antibody against B cell lymphoma can image the tumor early through ECT

locate the tumor mass accurately and suppress tumor growth through the mechanism of apoptosis and cell death. It can be a kind of potential and effective bioengineering medicine to treat the tumor in the area of radioimmunotherapy. Large high field MRI can provide effective

atraumatic and dynamic detection to the little animal model

and have wide application for little animal model.