Investigation of hepatic fibrosis with synchrotron X-ray diffraction enhanced imaging

LI Hui1; 2 WANG Tailing3 WANG Xueyan1 ZHAO Tao1 HU Chunhong1 LU Weiyuan1 WANG Baoen4 ZHAO Xinyan4 ZHU Peiping5 HUANG Wanxia5 YUAN Qingxi5 WANG Junyue5 LUO Shuqian1 1

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Investigation of hepatic fibrosis with synchrotron X-ray diffraction enhanced imaging

更新时间：2021-03-12

- Investigation of hepatic fibrosis with synchrotron X-ray diffraction enhanced imaging
- NUCLEAR TECHNIQUES Issue 2, (2008)
- 作者机构：
  
  1. 首都医科大学生物医学工程学院
  2. 中日友好医院病理科
  3. 首都医科大学附属北京友谊医院
  4. 中国科学院高能物理研究所
  5. 首都医科大学生物医学工程学院北京100069 北京大学医学部医学物理教研室北京,100083
  6. ,北京,100049
- 作者简介：
- 基金信息：
  
  国家自然科学基金(60532090,30770593)
- DOI：
  CLC： R575.2
- Published：01 February 2008
- 稿件说明：
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[1]李辉,王泰龄,王雪艳,赵涛,胡春红,鲁玮瑗,王宝恩,赵新颜,朱佩平,黄万霞,袁清习,王寯越,罗述谦.同步辐射衍射增强成像的肝纤维化成像研究[J].核技术,2008(02):81-86.

LI Hui1, 2 WANG Tailing3 WANG Xueyan1 ZHAO Tao1 HU Chunhong1 LU Weiyuan1 WANG Baoen4 ZHAO Xinyan4 ZHU Peiping5 HUANG Wanxia5 YUAN Qingxi5 WANG Junyue5 LUO Shuqian1 1. Investigation of hepatic fibrosis with synchrotron X-ray diffraction enhanced imaging[J]. Nuclear techniques, 2008, (2): 81-86.
[1]李辉,王泰龄,王雪艳,赵涛,胡春红,鲁玮瑗,王宝恩,赵新颜,朱佩平,黄万霞,袁清习,王寯越,罗述谦.同步辐射衍射增强成像的肝纤维化成像研究[J].核技术,2008(02):81-86. DOI：

LI Hui1, 2 WANG Tailing3 WANG Xueyan1 ZHAO Tao1 HU Chunhong1 LU Weiyuan1 WANG Baoen4 ZHAO Xinyan4 ZHU Peiping5 HUANG Wanxia5 YUAN Qingxi5 WANG Junyue5 LUO Shuqian1 1. Investigation of hepatic fibrosis with synchrotron X-ray diffraction enhanced imaging[J]. Nuclear techniques, 2008, (2): 81-86. DOI：

摘要

本文根据硬X射线衍射增强成像（Diffraction enhanced imaging

DEI）原理

对由人血白蛋白诱导的大鼠肝纤维化模型进行了成像研究。实验在北京同步辐射装置（Beijing Synchrotron Radiation Facility

BSRF）4W1A光束线形貌站完成。结果表明:正常及不同程度肝纤维化模型在DEI图像上差异显著

图像感兴趣区的光强分布及纹理测度也显示出这种差异。DEI成像为肝纤维化的诊断提供了一种潜在的影像学途径。

Abstract

In this paper

imaging investigation of hepatic fibrosis in rats induced by human albumin with hard X-ray diffraction enhanced imaging (DEI) is reported. The experiments were performed at 4W1A beamline of Beijing Syn- chrotron Radiation Facility (BSRF). The results show that great differences can be observed in DEI images between the normal and diseased rats in different stages of liver fibrosis. The difference can also be revealed by the profile curve and texture measurements on regions of interest. The results show that DEI may be a potential way for diagno- sis of hepatic fibrosis.

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Related Author

LIU Chenglin1

2 YAN Xiaohui1 ZHANG Xinyi1

3 ZHU Peiping4 HUANG Wanxia4 YUAN Qingxi4 1

朱佩平

黄万霞

袁清习

SU Zijing

LIU Haigang

Related Institution

Synchrotron Radiation Research Center, Physics Department, Surface Physics

中国科学院高能物理研究所上海200433 盐城师范学院物理系盐城

上海200433 上海针灸和经络研究所上海

Shanghai Advanced Research Institute, Chinese Academy of Sciences

Shanghai Institute of Applied Physics, Chinese Academy of Sciences

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