TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 LI Baoyuan1 LIANG Mingquan1 WANG Quanshi1 1. Automated synthesis of 18F-fluoroacetate via on-column hydrolysis[J]. Nuclear techniques, 2008, (5): 364-368.
TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 LI Baoyuan1 LIANG Mingquan1 WANG Quanshi1 1. Automated synthesis of 18F-fluoroacetate via on-column hydrolysis[J]. Nuclear techniques, 2008, (5): 364-368.DOI:
Automated synthesis of 18F-fluoroacetate via on-column hydrolysis
A simple and rapid automated synthetic technology of 18F-fluoroacetate(18F-FAC) is described in this pa-per.Automated synthesis of 18F-FAC was performed by 18F-fluorination of benzyl-2-bromoacetate as a precursor
on-column hydrolysis and Sep-Paks purification using a modifying commercial TRACERlab FXFN synthesizer.A high and reproducible radiochemical yield of above 60%(decay uncorrected) was obtained within the whole synthesis time less than 20 min.The radiochemical purity of 18F-FAC was >95%.The new
simple
and rapid on-column hydrolysis procedure should adaptable to the fully automated synthesis of 18F-FAC at commercial FDG synthesis module.