Studies on functional fractions of fructus trichosanthes cortex   by <sup>45</sup>Ca isotopic tracer technique

YANG Yuanyou  LIU Ning  QIU Mingfeng  MO Shangwu  WEI Jinxue  JIN Jiannan

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Studies on functional fractions of fructus trichosanthes cortex by ⁴⁵Ca isotopic tracer technique

更新时间：2021-03-12

- Studies on functional fractions of fructus trichosanthes cortex by ⁴⁵Ca isotopic tracer technique
- NUCLEAR TECHNIQUES Issue 5, (2002)
- 作者机构：
  
  1. 四川大学原子核科学技术研究所
  2. 四川大学原子核科学技术研究所辐射物理及技术教育部重点实验室成都,610064
- 作者简介：
- 基金信息：
  
  国家自然科学基金 (19775 0 34 );核工业基金 (Y7197QY4 14 )资助
- DOI：
  CLC： R284
- Published：01 May 2002
- 稿件说明：
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[1]杨远友,刘宁,邱明丰,莫尚武,韦锦学,金建南.用~(45)Ca同位素示踪技术研究瓜蒌皮具钙拮抗作用的活性成分[J].核技术,2002(05):345-348.

YANG Yuanyou LIU Ning QIU Mingfeng MO Shangwu WEI Jinxue JIN Jiannan. Studies on functional fractions of fructus trichosanthes cortex by ⁴⁵Ca isotopic tracer technique[J]. Nuclear techniques, 2002, (5): 345-348.
[1]杨远友,刘宁,邱明丰,莫尚武,韦锦学,金建南.用~(45)Ca同位素示踪技术研究瓜蒌皮具钙拮抗作用的活性成分[J].核技术,2002(05):345-348. DOI：

YANG Yuanyou LIU Ning QIU Mingfeng MO Shangwu WEI Jinxue JIN Jiannan. Studies on functional fractions of fructus trichosanthes cortex by ⁴⁵Ca isotopic tracer technique[J]. Nuclear techniques, 2002, (5): 345-348. DOI：

摘要

瓜蒌皮用不同浓度乙醇回流提取

拮抗实验表明

70 %乙醇提取物钙拮抗作用最强 ;将70 %乙醇提取物用石油醚萃取

萃取物经硅胶层析后的各组分

用4 5Ca跨膜测量方法研究其对大白兔主动脉PDC钙通道Ca2 + 内流的影响

以探明瓜蒌皮治疗冠心病的有效成分。结果表明

组分 1、4、5具有明显的钙拮抗作用

且组分 5活性最好 ;组分 3无钙拮抗作用反而有激动作用

Abstract

The active fractions of fructus trichosanthes cortex with antagonistic effect were studied by 45 Ca isotopic tracer technique- 45 Ca transmembrane influx technique. The fructus trichosanthes cortex was first extracted by 30-100% ethyl alcohol. The calcium antagonism of the extract obtained by 70% ethyl alcohol was found to be the highest. This extract was further extracted by petroleum ether

then isolated on Silica gel columm chromatography with elution of ethyl acetate and 95% ethyl alcohol. It was found that the eluates have five fractions. Among them

the fifth fraction had the strongest Ca 2+ antagonistic effect. In contrast

the third fraction has obvious activiating effect

but no antagonistic effect.

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Studies on functional fractions of fructus trichosanthes cortex by 45Ca isotopic tracer technique

DOI：

摘要

Abstract

关键词

Keywords

references

Studies on functional fractions of fructus trichosanthes cortex by ⁴⁵Ca isotopic tracer technique