Synthesis and labeling of   <sup>125/131</sup>I-FP-β-CIT as   a dopamine transporter imaging agent

FANG Ping  CHEN Zhengping  ZHOU Xiang

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Synthesis and labeling of ^125/131I-FP-β-CIT as a dopamine transporter imaging agent

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- Synthesis and labeling of ^125/131I-FP-β-CIT as a dopamine transporter imaging agent
- NUCLEAR TECHNIQUES Issue 2, (2002)
- 作者机构：
  
  1. 江苏省原子医学研究所核医学国家重点实验室
  2. 江苏省原子医学研究所核医学国家重点实验室,无锡,214063
- 作者简介：
- 基金信息：
  
  国家自然科学基金(39770230);卫生部科研基金(98-1-326);江苏省自然科学基金 (BK 9916 3);江苏省科委优秀科研骨干人才储备基金;江苏省卫生厅科研基金(H9732 );江苏省卫生厅重点科研基金(H2008)资助
- DOI：
  CLC： R817.4
- Published：01 February 2002
- 稿件说明：
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[1]方平,陈正平,周翔.多巴胺转运蛋白显像剂FP-β-CIT的合成及碘标记[J].核技术,2002(02):113-117.

FANG Ping CHEN Zhengping ZHOU Xiang. Synthesis and labeling of ^125/131I-FP-β-CIT as a dopamine transporter imaging agent[J]. Nuclear techniques, 2002, (2): 113-117.
[1]方平,陈正平,周翔.多巴胺转运蛋白显像剂FP-β-CIT的合成及碘标记[J].核技术,2002(02):113-117. DOI：

FANG Ping CHEN Zhengping ZHOU Xiang. Synthesis and labeling of ^125/131I-FP-β-CIT as a dopamine transporter imaging agent[J]. Nuclear techniques, 2002, (2): 113-117. DOI：

摘要

以可卡因为原料经水解、脱水、甲酯化、苯基溴镁格氏反应、脱N -甲基、碘化、N烷基化

烷基锡化等反应制备FP - β -CIT标记前体。用过氧乙酸法进行碘标记

得到131I -FP - β -CIT。标记率及放射化学纯度高（大于 95 % ）

稳定性好。

Abstract

The ligand of N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4’-iodo phenyl)nortropane (FP-β-CIT) and its tributylstannyl precursor were synthesized by hydrolysis of cocaine

and then dehydration

esterification

Grignard reaction

n-demethylation

iodination

n-alkylation and tributylstannylation. 125/131 I-FP-β-CIT were prepared by oxidation radioiododestannylation

using peroxyacetic acid as oxidant

of its tributylstannyl precursor. The stable labeled compound was synthesized with high radiochemical purity at pH 4-7.

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Related Institution

Key Laboratory of Nuclear Medicine, Ministry of Health, Key Laboratory of Molecular Nuclear Medicine of Jiangsu, Jiangsu Institute of Nuclear Medicine

上海大学环化学院

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江苏省原子医学研究所卫生部核医学重点实验室

Jiangsu Institute of Nuclear Medicine,Key Laboratory of Nuclear Medicine,Ministry of Health

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Synthesis and labeling of 125/131I-FP-β-CIT as a dopamine transporter imaging agent

DOI：

摘要

Abstract

关键词

Keywords

references

Synthesis and labeling of ^125/131I-FP-β-CIT as a dopamine transporter imaging agent