Quality control of 6-fluoro-L-DOPA

TANG Ganghua    1; 2  ZHANG Lan  1  TANG Xiaolan  2  WANG Mingfang  2    WANG Yongxian  1  HUANG Zuhan  2  YIN Duanzhi  1  1

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Quality control of 6-fluoro-L-DOPA

更新时间：2021-03-12

- Quality control of 6-fluoro-L-DOPA
- NUCLEAR TECHNIQUES Issue 11, (2002)
- 作者机构：
  
  1. 中国科学院上海原子核研究所放药中心
  2. 第一军医大学南方医院PET中心
  3. 中国科学院上海原子核研究所放药中心,上海,201800
  4. 第一军医大学南方医院PET中心广州,510515
  5. ,上海,201800
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目 (10 0 75 0 73);中国博士后科学基金项目;广东省自然科学基金项目 (C0 30 317)资助
- DOI：
  CLC： TQ463
- Published：01 November 2002
- 稿件说明：
移动端阅览
[1]唐刚华,张岚,唐小兰,王明芳,汪勇先,黄祖汉,尹端沚.6-[~(18)F]氟-L-多巴的质量控制[J].核技术,2002(11):918-923.

TANG Ganghua 1, 2 ZHANG Lan 1 TANG Xiaolan 2 WANG Mingfang 2 WANG Yongxian 1 HUANG Zuhan 2 YIN Duanzhi 1 1. Quality control of 6-fluoro-L-DOPA[J]. Nuclear techniques, 2002, (11): 918-923.
[1]唐刚华,张岚,唐小兰,王明芳,汪勇先,黄祖汉,尹端沚.6-[~(18)F]氟-L-多巴的质量控制[J].核技术,2002(11):918-923. DOI：

TANG Ganghua 1, 2 ZHANG Lan 1 TANG Xiaolan 2 WANG Mingfang 2 WANG Yongxian 1 HUANG Zuhan 2 YIN Duanzhi 1 1. Quality control of 6-fluoro-L-DOPA[J]. Nuclear techniques, 2002, (11): 918-923. DOI：

摘要

6 - [18F]氟 -L -多巴（18FDOPA

I）为L -多巴的类似物

是研究大脑突触前多巴胺能神经功能的正电子显像剂。为在临床上安全有效地使用18FDOPA

对合成的18FDOPA进行了较系统的质量控制研究

并建立了手性流动相HPLC法测定18FDOPA对映纯度

合成的18FDOPA各项质控指标符合药典的要求。本研究为研制新型PET显像剂提供了质量控制模式

为测定18FDOPA和其他L -型氨基酸的对映纯度提供了廉价而实用的方法。

Abstract

Fluoro-L-DOPA ( 18FDOPA)

an analogue of L-DOPA is a tracer for presynaptic dopamine function in cerebral studies with PET. In order to use it safely and effectively in clinical study

quality control of 18FDOPA was studied. Determination of the enantiomeric purity of 18FDOPA by HPLC method using a chiral mobil phase and reversed-phase C18 column was described. All quality criteria of 18FDOPA met the requirements of the local pharmacopoeia. The relevant details involved in quality control of 18FDOPA might be useful in the future development of new radiopharmaceuticals for PET.

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