Simple and rapid analysis of residual aminopolyether（K222） levels in [<sup>18</sup>F]-labeled imaging agents

TANG Xiaolan1 TANG Ganghua2; 3 LIAO Wenjie1 1

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Simple and rapid analysis of residual aminopolyether（K222） levels in [¹⁸F]-labeled imaging agents

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- Simple and rapid analysis of residual aminopolyether（K222） levels in [¹⁸F]-labeled imaging agents
- NUCLEAR TECHNIQUES Issue 11, (2008)
- 作者机构：
  
  1. 华南农业大学理学院
  2. 南方医科大学南方医院核医学科PET中心
  3. 中山大学附属第一医院核医学科PET-CT中心
- 作者简介：
- 基金信息：
  
  中山大学“百人计划”引进人才科研启动基金(80000-3171313)资助
- DOI：
  CLC： R817
- Published：01 November 2008
- 稿件说明：
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[1]唐小兰,唐刚华,廖文杰.~(18)F标记显像剂中氨基聚醚(K222)简单快速测定方法研究[J].核技术,2008(11):846-849.

TANG Xiaolan1 TANG Ganghua2, 3 LIAO Wenjie1 1. Simple and rapid analysis of residual aminopolyether（K222） levels in [¹⁸F]-labeled imaging agents[J]. Nuclear techniques, 2008, (11): 846-849.
[1]唐小兰,唐刚华,廖文杰.~(18)F标记显像剂中氨基聚醚(K222)简单快速测定方法研究[J].核技术,2008(11):846-849. DOI：

TANG Xiaolan1 TANG Ganghua2, 3 LIAO Wenjie1 1. Simple and rapid analysis of residual aminopolyether（K222） levels in [¹⁸F]-labeled imaging agents[J]. Nuclear techniques, 2008, (11): 846-849. DOI：

摘要

氨基聚醚（K222）是合成18F标记显像剂中最常用的催化剂

在18F标记显像剂用于临床之前K222通常是必须测定的质量控制指标。本文介绍半定量TLC碘显色法

用于测定18F标记显像剂中K222含量

并与分光光度法和TLC高锰酸钾溶液显色法进行了对照。TLC碘显色法简单快速

结果准确可靠。

Abstract

Aminopolyether(K222) is a commonly used catalyst in the routine preparation of [18F]-labeled tracers as PET imaging agents.Determination of residual K222 levels in [18F]-labeled radiopharmaceuticals is a quality control criterion required before they can be released for human use.However

there is no simple and rapid method for the determination of K222 levels.A universal iodine-vapor TLC stain method was developed for the semiquantitative analysis of K222 levels in [18F]-labeled radiopharmaceuticals in this study.Compared with the spectrophotometry and the potassium permanganate TLC stain approach

the iodine-vapor TLC stain method is simple

rapid

accurate and reliable.It can be used as a routine method for the determination of K222 levels.

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Simple and rapid analysis of residual aminopolyether（K222） levels in [18F]-labeled imaging agents

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摘要

Abstract

关键词

Keywords

references

Simple and rapid analysis of residual aminopolyether（K222） levels in [¹⁸F]-labeled imaging agents