Automatic synthesis of <sup>18</sup>F-FeCH as molecular imaging agent for tumor diagnosis

WANG Mingwei ZHANG Yingjian ZHANG Yongping YUAN Huiyu

doi:null

您当前的位置：

首页 >

文章列表页 >

Automatic synthesis of ¹⁸F-FeCH as molecular imaging agent for tumor diagnosis

更新时间：2021-03-12

- Automatic synthesis of ¹⁸F-FeCH as molecular imaging agent for tumor diagnosis
- NUCLEAR TECHNIQUES Issue 11, (2008)
- 作者机构：
  
  复旦大学附属肿瘤医院核医学科PET中心,复旦大学上海医学院肿瘤学系
- 作者简介：
- 基金信息：
  
  上海市卫生局青年科研项目(2006Y11);国家自然科学基金(30700188)资助
- DOI：
  CLC： R817
- Published：01 November 2008
- 稿件说明：
移动端阅览
[1]王明伟,章英剑,张勇平,袁慧瑜.肿瘤分子显像剂~(18)F-氟乙基胆碱的自动化合成[J].核技术,2008(11):859-863.

WANG Mingwei ZHANG Yingjian ZHANG Yongping YUAN Huiyu. Automatic synthesis of ¹⁸F-FeCH as molecular imaging agent for tumor diagnosis[J]. Nuclear techniques, 2008, (11): 859-863.
[1]王明伟,章英剑,张勇平,袁慧瑜.肿瘤分子显像剂~(18)F-氟乙基胆碱的自动化合成[J].核技术,2008(11):859-863. DOI：

WANG Mingwei ZHANG Yingjian ZHANG Yongping YUAN Huiyu. Automatic synthesis of ¹⁸F-FeCH as molecular imaging agent for tumor diagnosis[J]. Nuclear techniques, 2008, (11): 859-863. DOI：

摘要

18F-氟标记的胆碱衍生物18F-氟乙基胆碱（18F-FeCH）对前列腺癌等多种肿瘤的显像诊断均比较敏感

具有良好的临床应用前景。本文基于"两步-一锅法"

经过对商品化Explora FDG4合成模块进行合理的改装发展了18F-FeCH的自动化合成方法。第一步是18F离子与1

2-二对甲苯磺酰基乙烷的亲核取代反应

90℃反应5min

生成标记中间体18F-氟乙基对甲苯磺酰酯。第二步是18F-氟乙基对甲苯磺酰酯与N

N-二甲基-2-羟乙基铵之间的烷基化反应

100℃反应8min

经过Sep-pak硅胶柱分离

获得目标产物18F-FeCH。总合成时间约65min

放射化学产率为30%（未衰变校正）

放射化学纯度大于99%。

Abstract

18F-Fluoroethylcholine(18F-FeCH)

a 18F-labeled choline derivatives

is a very sensitive molecular imaging agent for diagnosis of prostate cancer and other types of cancers

indicating a promising future for clinic applications.In this study

automatic synthesis of 18F-FeCH was developed using a "two-step one-pot" method modified from Explora FDG4 synthesis module that are commercially available.The first step is the nucleophilic displacement reaction of 18F-fluoride and 1

2-bis(tosyloxy)ethane at 90°C for 5 min to form labeled intermediate 18F-fluoroethyltosylate.The second step is to form alkylation between 18F-fluoroethyltosylate and N

N-dimethyl-2-hydroxyethylammonium at 100°C for 8 min.The target product of 18F-FeCH was obtained via Sep-pak cartridge separation with about 30% of radiochemical yields(no decay corrected) and more than 99% of radiochemical purity within 65 min of total synthesis time.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module

Automated synthesis of novel cell death imaging tracer 18F-FPDuramycin

Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma

Automated synthesis of ¹⁸F-fluorothymidine via Sep-Pak purification

Impact of PET/CT on precision and accuracy of radiotherapy planning for patients with non-small cell lung cancer

Related Author

Jinming ZHANG

Yungang LI

Xiaojun ZHANG

Haifeng LI

HU Kongzhen

YAO Shaobo

TANG Ganghua

LIANG Xiang

Related Institution

Department of Nuclear Medicine, The People's Liberation Army(PLA) General Hospital

Department of Nuclear Medicine, Jiang Xi Cancer Hospital

Department of Nuclear Medicine, the First Af?liated Hospital,Sun Yat-Sen University

School of Pharmaceutical Science and Technology, Tianjin University

PET Center Nanfang Hospital,Sourthern Medical University,Guangzhou 510515,China) 2

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881163 Visits Today：690

⁰

Automatic synthesis of 18F-FeCH as molecular imaging agent for tumor diagnosis

DOI：

摘要

Abstract

关键词

Keywords

references

Automatic synthesis of ¹⁸F-FeCH as molecular imaging agent for tumor diagnosis