A study on anti-angiogenesis peptides labeled with <sup>99</sup>Tc<sup>m</sup>

LIU Ciyi ZEN Jun HUANG Gang

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A study on anti-angiogenesis peptides labeled with ⁹⁹Tc^m

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- A study on anti-angiogenesis peptides labeled with ⁹⁹Tc^m
- NUCLEAR TECHNIQUES Issue 9, (2008)
- 作者机构：
  
  上海交通大学医学院附属仁济医院核医学科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R73-3;R817
- Published：01 September 2008
- 稿件说明：
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[1]刘慈懿,曾骏,黄钢.~(99)Tc~m标记的肿瘤血管化特异性多肽的实验研究[J].核技术,2008(09):692-697.

LIU Ciyi ZEN Jun HUANG Gang. A study on anti-angiogenesis peptides labeled with ⁹⁹Tc^m[J]. Nuclear techniques, 2008, (9): 692-697.
[1]刘慈懿,曾骏,黄钢.~(99)Tc~m标记的肿瘤血管化特异性多肽的实验研究[J].核技术,2008(09):692-697. DOI：

LIU Ciyi ZEN Jun HUANG Gang. A study on anti-angiogenesis peptides labeled with ⁹⁹Tc^m[J]. Nuclear techniques, 2008, (9): 692-697. DOI：

摘要

本文旨在寻找一种的99Tcm标记的抗肿瘤血管化的显像剂。将具抗肿瘤血管化的多肽适当修饰后

用99Tcm标记

并在肿瘤荷鼠体内筛选比较。选择在肿瘤部位放射性浓聚明显的多肽

进行肿瘤荷鼠的体内分布和竞争试验。GPRPAA（D）A（D）-HYNIC-99Tcm标记率高、产物稳定

放化纯度>98%

室温下6h后>93%。能在荷鼠肿瘤组织较快浓聚

0.5h时肿瘤%ID/g为13.5973±1.3642

清除较慢

6h肿瘤%ID/g仍有4.0399±0.5876;血及其它血供丰富的组织清除较快

1h时血ID/g为1.7035±0.2742

心%ID/g为3.2578±1.3121

肿瘤在2h显像清晰。GPRPAA（D）A（D）-HYNIC-99mTc有希望成为一种肿瘤血管化显像剂。

Abstract

This work was aimed at finding a 99Tcm-labeled tracer for tumor angiogenesis studies. Anti-angiogenesis peptides

with appropriate structural modified

were labeled with 99Tcm and screening in vivo on the tumor-bearing mice. The anti-angiogenesis peptide that has the highest accumulation of radioactivity in tumor was chosen for the tissue distribution and tumor competition on the tumor bearing mice. The GPRPAA(D)A(D)-HYNIC-99Tcm had strong activity distribution in tumor with very low background activities in other tissues

and was quite stable with high radio labeling ratio. GPRPAA(D)A(D)-HYNIC-99 Tcm could become a tracer of tumor angiogenesis.

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A study on anti-angiogenesis peptides labeled with 99Tcm

DOI：

摘要

Abstract

关键词

Keywords

references

A study on anti-angiogenesis peptides labeled with ⁹⁹Tc^m