Synthesis  of <sup>14</sup>C  labeled  lidocaine   （α-diethylaminoacet-2,6-dimethylanilide）

ZHOU Zhentang  QIAN Guojun  LIN Fenzhi  ZHUANG Daoling  ZHANG Yulong  HE Zhanjun

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Synthesis of ¹⁴C labeled lidocaine （α-diethylaminoacet-2,6-dimethylanilide）

更新时间：2021-03-12

- Synthesis of ¹⁴C labeled lidocaine （α-diethylaminoacet-2,6-dimethylanilide）
- NUCLEAR TECHNIQUES Issue 1, (2002)
- 作者机构：
  
  1. 中国科学院上海原子核研究所
  2. 上海第二军医大学东方肝胆外科医院
  3. 中国科学院上海原子核研究所,上海,201800
  4. ,上海,200433
- 作者简介：
- 基金信息：
  
  国家攀登B项目 (85 - 45 - 0 5 - 0 1)资助
- DOI：
  CLC： TQ463
- Published：01 January 2002
- 稿件说明：
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[1]周桢堂,钱国军,林奋智,庄道玲,张雨龙,贺战军.~(14)C标记利多卡因(二乙基甘氨酰二甲苯胺)的合成[J].核技术,2002(01):54-56.

ZHOU Zhentang QIAN Guojun LIN Fenzhi ZHUANG Daoling ZHANG Yulong HE Zhanjun. Synthesis of ¹⁴C labeled lidocaine （α-diethylaminoacet-2,6-dimethylanilide）[J]. Nuclear techniques, 2002, (1): 54-56.
[1]周桢堂,钱国军,林奋智,庄道玲,张雨龙,贺战军.~(14)C标记利多卡因(二乙基甘氨酰二甲苯胺)的合成[J].核技术,2002(01):54-56. DOI：

ZHOU Zhentang QIAN Guojun LIN Fenzhi ZHUANG Daoling ZHANG Yulong HE Zhanjun. Synthesis of ¹⁴C labeled lidocaine （α-diethylaminoacet-2,6-dimethylanilide）[J]. Nuclear techniques, 2002, (1): 54-56. DOI：

摘要

14 C -利多卡因由14 C -二乙胺和ω -氯乙酰 - 2

6 -二甲基苯胺缩合制得

而14 C -二乙胺由Ba14 CO3 途径K14 CN和CH3 14 CN氢化而制得。14 C -二乙胺和14 C -利多卡因各自用HPLC和TLC检定放化纯度 >99%。它为研究肝储备功能动物呼气试验提供了有力的手段。

Abstract

C-lidocaine was composed by 14 C-diethylamine reaction with ω-chloroacetic-2

6-dimethylaniline. 14 C-diethylamine was prepared from Ba 14 CO 3 via K 14CN and 14 C-acetenitrile which was hydrogenated. Radiochemical purity of 14 C-diethylamine and 14 C-lidocaine is >99% by HPLC and TLC respectively. 14 C-lidocaine is needed for breath assay of mouse for measuring liver function.

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Synthesis of 14C labeled lidocaine （α-diethylaminoacet-2,6-dimethylanilide）

DOI：

摘要

Abstract

关键词

Keywords

references

Synthesis of ¹⁴C labeled lidocaine （α-diethylaminoacet-2,6-dimethylanilide）