AFP-combined <sup>18</sup>F-FDG PET/CT detection of PHC and its recurrence

WU Shuqi1 LI Jin2 LIU Jianjun1 CHEN Tao1 SHI Yiping1 CHEN Yumei1 Song Shaoli1 WAN Liangrong1 Huang Gang1 1

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AFP-combined ¹⁸F-FDG PET/CT detection of PHC and its recurrence

更新时间：2021-03-12

- AFP-combined ¹⁸F-FDG PET/CT detection of PHC and its recurrence
- NUCLEAR TECHNIQUES Issue 10, (2007)
- 作者机构：
  
  1. 上海交通大学医学院临床核医学研究所暨仁济医院核医学科
  2. 东方肝胆外科医院
- 作者简介：
- 基金信息：
  
  上海市百人计划第三轮重点资助(97BR012);上海市科委重点基金项目(02DJ14037);上海市教委重点发展基金(04BA03)
- DOI：
  CLC： R735.7
- Published：01 October 2007
- 稿件说明：
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[1]吴书其,李瑾,刘建军,陈涛,施一平,陈虞梅,宋少莉,万良荣,黄钢.~(18)F-FDGPET/CT联合甲胎蛋白在原发性肝癌诊断与复发监测中的应用研究[J].核技术,2007(10):855-859.

WU Shuqi1 LI Jin2 LIU Jianjun1 CHEN Tao1 SHI Yiping1 CHEN Yumei1 Song Shaoli1 WAN Liangrong1 Huang Gang1 1. AFP-combined ¹⁸F-FDG PET/CT detection of PHC and its recurrence[J]. Nuclear techniques, 2007, (10): 855-859.
[1]吴书其,李瑾,刘建军,陈涛,施一平,陈虞梅,宋少莉,万良荣,黄钢.~(18)F-FDGPET/CT联合甲胎蛋白在原发性肝癌诊断与复发监测中的应用研究[J].核技术,2007(10):855-859. DOI：

WU Shuqi1 LI Jin2 LIU Jianjun1 CHEN Tao1 SHI Yiping1 CHEN Yumei1 Song Shaoli1 WAN Liangrong1 Huang Gang1 1. AFP-combined ¹⁸F-FDG PET/CT detection of PHC and its recurrence[J]. Nuclear techniques, 2007, (10): 855-859. DOI：

摘要

研究了18F-FDGPET/CT与甲胎蛋白（AFP）对原发性肝癌（PLC）的诊断与复发监测效能

并初步探讨两者联检的意义。分析了63例临床或病理证实PLC患者的72次全身PET/CT显像结果

根据每位患者的近期AFP水平

分为AFP阳性组和阴性组

结合临床随访及病理结果

独立统计各组灵敏度（Se）和阳性预测值（PPV）。单独18F-FDGPET的Se为73.24%

PPV为98.11%;单独AFP的Se为73.24%

PPV为100.00%。但在AFP阳性组

PET的Se和PPV被明显提高

分别为80.77%、100.00%;相反在AFP阴性组两者则被降低

分别为52.63%、90.91%。另外

63例病人中

有59例检出共98处器官转移。本研究结果表明:①PET/CT对AFP在PLC诊断和复发监测中有显著的辅助作用

特别是AFP阳性病例;②PET/CT在PLC转移灶的检出作用好于单独PET或CT

对临床PLC分期及预后有较大作用。

Abstract

The paper is to analyze the value of 18F-FDG PET/CT

which is combined with alpha-fetoprotein(AFP)

in detecting primary hepatic carcinoma(PLC) and monitoring its recurrence. 18F-FDG PET/CT images of 63 patients(72 studies) with PLC confirmed by histology or clinic were retrospectively analyzed. According to serum AFP

they were divided into positive and negative group. By the results of histology and follow-up

the diagnostic values were calculated respectively. The sensitivity and positive predictive value of PET/CT was 73.24% and 98.11%

vs AFP 73.24% and 100.00% respectively

in detection and monitoring recurrence of PLC. In AFP positive group

sensitivity and positive predictive value for PET were higher than they were in AFP negative group

(80.77% and 100.00% vs 52.63% and 90.91%

respectively) . In addition

98 metastasis were discovered in 59 cases of the 63 patients. It is con-cluded that 18F-FDG PET/CT is a outstanding aid to AFP in detection PLC and in monitoring recurrence of HCC

es-pecially in cases with abnormal serum AFP levels

and.PET/CT is a more powerful method in detecting metastasis of PLC than PET or CT. And in tumor staging and predict prognosis

PET/CT appears to be a very useful method.

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AFP-combined 18F-FDG PET/CT detection of PHC and its recurrence

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摘要

Abstract

关键词

Keywords

references

AFP-combined ¹⁸F-FDG PET/CT detection of PHC and its recurrence