Calculation of the internal radiation absorbed dose of   <sup>99m</sup>Tc-TRODAT-1

JIANG Zhong  WANG Feng  LIU Zengli  TANG Jun  WU Jinchang

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Calculation of the internal radiation absorbed dose of ^99mTc-TRODAT-1

更新时间：2021-03-12

- Calculation of the internal radiation absorbed dose of ^99mTc-TRODAT-1
- NUCLEAR TECHNIQUES Issue 11, (2002)
- 作者机构：
  
  1. 苏州大学附属第二医院核医学科
  2. 苏州大学核医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817.4
- Published：01 November 2002
- 稿件说明：
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[1]姜忠,王峰,刘增礼,唐军,吴锦昌.~(99m)Tc-TRODAT-1内照射辐射吸收剂量的计算[J].核技术,2002(11):961-965.

JIANG Zhong WANG Feng LIU Zengli TANG Jun WU Jinchang. Calculation of the internal radiation absorbed dose of ^99mTc-TRODAT-1[J]. Nuclear techniques, 2002, (11): 961-965.
[1]姜忠,王峰,刘增礼,唐军,吴锦昌.~(99m)Tc-TRODAT-1内照射辐射吸收剂量的计算[J].核技术,2002(11):961-965. DOI：

JIANG Zhong WANG Feng LIU Zengli TANG Jun WU Jinchang. Calculation of the internal radiation absorbed dose of ^99mTc-TRODAT-1[J]. Nuclear techniques, 2002, (11): 961-965. DOI：

摘要

为估测99mTc -TRODAT - 1在全身靶器官的内照射辐射吸收剂量及生物学分布

对 3例帕金森病患者（PD）、2例原发性震颤（ET）患者静脉注射99mTc -TRODAT - 1后

用双探头SPECT采集 2 4h内系列全身前、后位图像 ;利用ROI技术获各时相全身各脏器的摄取放射性活度

采用MicrocalOrigin 5 .0应用程序中的非线性拟合方法得到各脏器的时间 -放射性曲线

通过各源器官的累积活度计算出放射性核素的滞留时间

然后由美国MIRDOSE 3.1应用程序得到各靶器官的内照射辐射吸收剂量。另外

注药后 3h进行脑断层显像。实验结果显示

99mTc -TRO DAT - 1全身各脏器内照射辐射吸收剂量均较小

脑断层显像

纹状体影像清晰。99mTc -TRO DAT - 1人体应用安全

是一种优良的多巴胺转运体（DAT）显像剂。

Abstract

To evaluate the radiobiodistribution and internal dosimetry of 99mTc-TRODAT-1 in human target organs. Three patients with Pakinson’ s disease (PD) and two patients with essential tremor (ET) were included. After injection of 99mTc-TRODAT-1 intravenously

serial whole body scans were aquired during the following 24h by dual-head SPECT. Radioactivity uptakes were estimated applying ROI technique and radioactivity-time curves in target organs were obtained with non-linear regression analysis in terms of Microcal Origin 5.0 software. Residence time was calculated from the accumulative activity. All data of the residence times were input to the MIRDOSE 3.1 software to create the organ-absorbed dose. Brain tomography for each patient was performed 3h post injection. The experimental results showed that the internal absorbed dose from 99mTc-TRODAT-1 in target organs was small and the striatum was clearly imaged. Also

demonstrates that 99mTc-TRODAT-1 is a safe and ideal radio tracer to visualize the changes of dopamine transporter in striatum.

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Calculation of the internal radiation absorbed dose of 99mTc-TRODAT-1

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Calculation of the internal radiation absorbed dose of ^99mTc-TRODAT-1