The difference of<sup>188</sup>Re radiation on proliferation of   smooth muscle cells and endothelial cells

HUANG Gang  REN Xiaoqing  CHEN Jianwei  MAO Jialiang  HUANG Dingju  1

doi:null

您当前的位置：

首页 >

文章列表页 >

The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells

更新时间：2021-03-12

- The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells
- NUCLEAR TECHNIQUES Issue 11, (2002)
- 作者机构：
  
  1. 上海第二医科大学附属仁济医院核医学科
  2. 上海第二医科大学附属仁济医院核医学科,上海,200001
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助课题 (批准号39970 2 2 1);上海市百人计划第二轮重点资助 (编号 :97BR0 12 );上海市教委发展基金 (编号 :98B15 )
- DOI：
  CLC： R817.5
- Published：01 November 2002
- 稿件说明：
移动端阅览
[1]黄钢,任晓庆,陈建伟,毛家亮,黄定九.~(188)Re对血管平滑肌与内皮细胞的辐射差异性[J].核技术,2002(11):901-906.

HUANG Gang REN Xiaoqing CHEN Jianwei MAO Jialiang HUANG Dingju 1. The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells[J]. Nuclear techniques, 2002, (11): 901-906.
[1]黄钢,任晓庆,陈建伟,毛家亮,黄定九.~(188)Re对血管平滑肌与内皮细胞的辐射差异性[J].核技术,2002(11):901-906. DOI：

HUANG Gang REN Xiaoqing CHEN Jianwei MAO Jialiang HUANG Dingju 1. The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells[J]. Nuclear techniques, 2002, (11): 901-906. DOI：

摘要

为比较 β射线对平滑肌和内皮细胞的增殖抑制作用

探寻血管内放射治疗中保护内皮细胞的措施

应用放射性核素188Reβ射线对培养的平滑肌细胞和内皮细胞进行了辐射。通过细胞增殖计数、细胞增殖周期分析和3 H -TdR掺入实验观察

研究辐射对平滑肌和内皮细胞在增殖方面的影响。结果显示

5 .2Gy剂量 β辐射

平滑肌细胞增殖计数、细胞增殖率、3 H -TdR掺入率显著下降

而内皮细胞的上述指标则无明显改变 ;高于 10Gy

小于 2 0Gy的剂量辐射

两组细胞的增殖均受到明显抑制。表明在体外细胞培养条件下

平滑肌细胞及内皮细胞对高剂量 β辐射的敏感性一致

而对低剂量 β辐射

内皮细胞较平滑肌细胞耐受。 5 .2Gy低剂量 β辐射

是一个既能有效抑制平滑肌细胞增殖

又不影响内皮细胞增殖

且对心肌细胞无损伤作用的血管内放疗窗口。

Abstract

To compare the effects of β-particle radiation on proliferation of smooth muscle cells and endothelial cells

and to explore the methods for protecting endothelial cells during endovascular radiotherapy

the smooth muscle cells and endothelial cells cultured in vitro were irradiated by 188Re with different single doses. By means of proliferation cell count

cell cycle progression analysis

3H-TdR incorperation

the effects of β-particle on proliferation of smooth muscle cells (SMCs) and endothelial cells (ECs) were studied and compared. SMCs proliferation

but not ECs

was significantly inhibited by β-particle irradiation with dose of 5.2Gy. SMCs and ECs were inhibited similarly by β-particle irradiation with doses >10.3Gy and <20Gy. ECs appeared to be more radioresistant than SMCs at a lower dose. A safety window of treatment with 188Re at a dose of 5.2Gy was found between the smooth muscle cells and endothelial cells cultured in vitro.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Experimental study on the labeling of antisense oligonucleotide from U87-EGFRvIII glioma cells with 188Re

Synthesis and radiolabelling of ¹⁸⁸Re labeled dendrimer PAMAM-folic acid conjugate

Recent progresses in ¹⁸⁸Re labeling biomolecules

Preparation of ¹⁸⁸Re-NEPTDD and its biodistribution

Preparation of ¹⁸⁸Re-MAG₃ and in vivo evaluation in mice

Related Author

HUANG Baodan

DU Li

ZHANG Hui

HUANG Kai

LI Guiping

QI Yongshuai

CUI Wei~

张元庆

Related Institution

Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University

1,2) ZHANG Yuanqing~

中国科学院研究生院

上海交通大学系统生物医学研究院系统生物医学教育部重点实验室

Shanghai Institute of Applied Physics, China Academy of Sciences, Shanghai 201800, China) 2

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：881003 Visits Today：530

⁰

The difference of188Re radiation on proliferation of smooth muscle cells and endothelial cells

DOI：

摘要

Abstract

关键词

Keywords

references

The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells