The radiation from 32P-GTMS was used to suppress the proliferation of prostate mesenchymal cell and improve the symptom of dysuria. (1) 25mg/kg of testosterone propionate were intramuscularly injected into 5 male healthy dogs three times a week for 30 days to establish the prostate proliferation model. Under the guidance of ultrasonography 9.25-74mBq/mL of 32P-GTMS were injected and 30

60

90 days post injection biopsy were examined to get the data of prostate destruction and its shrinking. Another 2 dogs were not treated with 32P-GTMS

but injected with testosterone propionate to serve as controls. Then we compare the rate of proliferatioe of prostate proliferation. (2) According to the data from dogs

111±18.5mBq of 32P-GTMS were injected to 34 prostate proliferation patients under the guidance of ultrasonography and the prostate volume

urine flow

remnant urine and I-PSS scores were recorded at 30

60 and 90 days post injection. In dogs

30 days after the injection of testosterone propionate

the prostate were enlarged more than 2 times. After treatment with 32P-GTMS

5 dogs all showed cytometaplasia and mesenchymal cell infiltration. After 90 days the average shrinking rate was larger than 43.4%

the average shrinking rate of compare group was loss than 13%. The average shrinking rate of 34 cases of prostate proliferation patients are 17% and the urine flow increased by 41%

remnant urine were decreased by 74% and I-PSS score decreased by 31%

(P<0.01). Pathological sections showed degeneration and atrophy of the prostate measenchymal cell. The method is an easy and non- painful way that can shrink the prostate and make the emiction freely.