Radioactive synthesis of β-elemene Re（CO）<sub>3</sub> derivative

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Radioactive synthesis of β-elemene Re（CO）₃ derivative

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- Radioactive synthesis of β-elemene Re（CO）₃ derivative
- NUCLEAR TECHNIQUES Issue 1, (2007)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所
  2. 中国科学院上海应用物理研究所上海 201800 中国科学院研究生院
  3. ,北京,100049
- 作者简介：
- 基金信息：
- DOI：
  CLC： O644.2;TQ460.1
- Published：01 January 2007
- 稿件说明：
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[1]成康民,沈玉梅.β-榄香烯三羰基铼衍生物的放射化学合成[J].核技术,2007(01):53-56.

Radioactive synthesis of β-elemene Re（CO）₃ derivative[J]. Nuclear techniques, 2007, (1): 53-56.
[1]成康民,沈玉梅.β-榄香烯三羰基铼衍生物的放射化学合成[J].核技术,2007(01):53-56. DOI：

Radioactive synthesis of β-elemene Re（CO）₃ derivative[J]. Nuclear techniques, 2007, (1): 53-56. DOI：

摘要

本文报道了β-榄香烯三羰基铼衍生物的合成及其同位素188Re标记。标记配体由β-榄香烯与双功能螯合剂二（2-吡啶甲基）-胺反应制得。标记产物直接由配体与fac-[188Re（CO）3（H2O）3]+制得

并经反向HPLC分离纯化。结果显示

标记配体收率为64%

标记产物放化产率40%

经HPLC分离后放化纯度达到95%以上。表明该法简单易行

其标记化合物有可能发展成为一种新的放射性药物。

Abstract

This paper describes the preparation ofβ-elemene derivative of Re(C0)3 and[188Re]-1abelled radioactiveβ-elemene derivative of Re(CO)3.β-elemene derivative was synthesized by purifiedβ-elemene with di-(2-picoyl)amine.Radioactiveβ-elemene derivative of Re(CO)3 was synthesized byβ-elemene di-(2-picoyl)amine with fac-[188Re(CO)3(H20)3]+ and purified by C18 reverse phase HPLC.β-elemene derivative was synthesized at a yield of 64%.Radioactiveβ-elemene derivative of Re(CO)3 was prepared with a radiochemical yield of 40% and a radiochemical purity of greater than 95%.It is concluded that this process is economic and suited for preparing ra-dioactiveβ-elemene derivative of Re(CO)3 which may become a potential therapeutic radiopharmaceuticals in the fu-ture.

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第四军医大学西京医院核医学科

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Radioactive synthesis of β-elemene Re（CO）3 derivative

DOI：

摘要

Abstract

关键词

Keywords

references

Radioactive synthesis of β-elemene Re（CO）₃ derivative