A study of protective action of different scavengers on DNA damage induced by γ rays

YANG Mingjian1; 2 KONG Fuquan1 ZHAN Yong2 WANG Xiao1 NI Meinan1 SUI Li1 CAI Minghui1; 2 ZHAO Kui1; 3 1

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A study of protective action of different scavengers on DNA damage induced by γ rays

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- A study of protective action of different scavengers on DNA damage induced by γ rays
- NUCLEAR TECHNIQUES Issue 4, (2007)
- 作者机构：
  
  1. 中国原子能科学研究院
  2. 河北工业大学理学院天津,300130
  3. 北京师范大学射线束技术与材料改性教育部重点实验室北京100875,北京,102413
- 作者简介：
- 基金信息：
  
  国家自然科学基金(10435020);中国原子能科学研究院院长基金;中国原子能科学研究院核物理所所长基金(12SZZ-200602)资助
- DOI：
  CLC： Q345
- Published：01 April 2007
- 稿件说明：
移动端阅览
[1]杨明建,孔福全,展永,王潇,倪嵋楠,隋丽,蔡明辉,赵葵.各种自由基清除剂在γ射线辐照DNA损伤中的作用[J].核技术,2007(04):255-258.

YANG Mingjian1, 2 KONG Fuquan1 ZHAN Yong2 WANG Xiao1 NI Meinan1 SUI Li1 CAI Minghui1, 2 ZHAO Kui1, et al. A study of protective action of different scavengers on DNA damage induced by γ rays[J]. Nuclear techniques, 2007, (4): 255-258.
[1]杨明建,孔福全,展永,王潇,倪嵋楠,隋丽,蔡明辉,赵葵.各种自由基清除剂在γ射线辐照DNA损伤中的作用[J].核技术,2007(04):255-258. DOI：

YANG Mingjian1, 2 KONG Fuquan1 ZHAN Yong2 WANG Xiao1 NI Meinan1 SUI Li1 CAI Minghui1, 2 ZHAO Kui1, et al. A study of protective action of different scavengers on DNA damage induced by γ rays[J]. Nuclear techniques, 2007, (4): 255-258. DOI：

摘要

为了对重离子辐照致DNA损伤中的自由基作用进行评估

本文利用γ射线对添加了各种自由基清除剂（甘露醇

维生素C和茶多酚）的质粒DNA进行辐照

凝胶电泳分析的结果表明

三种自由基清除剂对DNA均有很好的保护作用。在相同自由基清除剂浓度的情况下

甘露醇比维生素C具有更强的清除自由基的作用。与重离子辐照情况相比

这几种自由基清除剂对γ射线产生的自由基的清除作用更为明显。

Abstract

To evaluate the effect of free radicals on DNA damage induced by heavy ions

pUC19 plasmid DNA solution with different kinds of scavengers(Mannitol

Vitamin C and Tea Polyphenols) is irradiated by γ rays. The DNA damages are analysed by gel electrophoresis and Alpha Innotech digital imaging system. The results show that all of the three kinds of scavengers can significantly protect DNA;mannitol is more effective than Vitamin C under the same condition;and their capacity of scavenging free radicals induced by γ rays is more remarkable than those induced by heavy ions.

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