Preparation and bio-distribution of <sup>125</sup>I-fullerene pyrrolidine benzoyl nitrogen mustard

RAN Tiecheng1; 2 LIU Ruili1; 2 ZHU Ying1; 2 LI Qingnuan1 ZHU Jianhua3 LI Wenxin1 1

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Preparation and bio-distribution of ¹²⁵I-fullerene pyrrolidine benzoyl nitrogen mustard

更新时间：2021-03-12

- Preparation and bio-distribution of ¹²⁵I-fullerene pyrrolidine benzoyl nitrogen mustard
- NUCLEAR TECHNIQUES Issue 4, (2007)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所纳米生物医药研究室
  2. 中国科学院研究生院北京,100049
  3. 复旦大学药学院
  4. 中国科学院上海应用物理研究所纳米生物医药研究室,上海,201800
  5. ,上海,200032
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(30300439和20302012);MOST973项目(2006CB705600)资助
- DOI：
  CLC： R817
- Published：01 April 2007
- 稿件说明：
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[1]冉铁成,刘瑞丽,诸颖,李晴暖,朱建华,李文新.~(125)I-C_(60)吡咯烷苯氮芥的制备和生物分布[J].核技术,2007(04):373-375.

RAN Tiecheng1, 2 LIU Ruili1, 2 ZHU Ying1, et al. Preparation and bio-distribution of ¹²⁵I-fullerene pyrrolidine benzoyl nitrogen mustard[J]. Nuclear techniques, 2007, (4): 373-375.
[1]冉铁成,刘瑞丽,诸颖,李晴暖,朱建华,李文新.~(125)I-C_(60)吡咯烷苯氮芥的制备和生物分布[J].核技术,2007(04):373-375. DOI：

RAN Tiecheng1, 2 LIU Ruili1, 2 ZHU Ying1, et al. Preparation and bio-distribution of ¹²⁵I-fullerene pyrrolidine benzoyl nitrogen mustard[J]. Nuclear techniques, 2007, (4): 373-375. DOI：

摘要

在合成以富勒烯为载体的抗肿瘤药物C60吡咯烷苯氮芥的基础上

采用先结合稳定碘再进行同位素交换的方法制备了125I-C60吡咯烷苯氮芥。研究了125I-C60吡咯烷苯氮芥的聚乙烯吡咯烷位酮（PVP）溶液通过爪垫皮下注射在大鼠体内的生物分布。实验结果表明

125I-C60吡咯烷苯氮芥具有较理想的淋巴摄取。

Abstract

The synthesized C60NM

after connecting with the stable iodine

was radiolabeled with iodine-125 through isotope exchanging. The bio-distribution of the radioiodinated compound in rats was studied. The results indicated that 125I-C60NM can target in lymphatic node and it has a good lympha targeting effect.

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Department of Chemistry, Beijing Normal University

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Preparation and bio-distribution of 125I-fullerene pyrrolidine benzoyl nitrogen mustard

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摘要

Abstract

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Preparation and bio-distribution of ¹²⁵I-fullerene pyrrolidine benzoyl nitrogen mustard