Investigation of direct and indirect interaction of DNA damage induced by high LET ~7Li ions

SUI Li1 GUO Jiyu1 KONG Fuquan1 NI Meinan1 CAI Minghui1; 2 YANG Mingjian1; 2 LIU Jiancheng1 ZHAO Kui1; 3 1

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Investigation of direct and indirect interaction of DNA damage induced by high LET ~7Li ions

更新时间：2021-03-12

- Investigation of direct and indirect interaction of DNA damage induced by high LET ~7Li ions
- NUCLEAR TECHNIQUES Issue 4, (2007)
- 作者机构：
  
  1. 中国原子能科学研究院核物理所
  2. 河北工业大学理学院天津,300130
  3. 北京师范大学射线束技术与材料改性教育部重点实验室北京100875,北京,102413
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助(10435020)项目
- DOI：
  CLC： Q345
- Published：01 April 2007
- 稿件说明：
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[1]隋丽,郭继宇,孔福全,倪嵋楠,蔡明辉,杨明建,刘建成,赵葵.高LET的~7Li离子致DNA损伤的直接和间接作用研究[J].核技术,2007(04):250-254.

SUI Li1 GUO Jiyu1 KONG Fuquan1 NI Meinan1 CAI Minghui1, 2 YANG Mingjian1, 2 LIU Jiancheng1 ZHAO Kui1, et al. Investigation of direct and indirect interaction of DNA damage induced by high LET ~7Li ions[J]. Nuclear techniques, 2007, (4): 250-254.
[1]隋丽,郭继宇,孔福全,倪嵋楠,蔡明辉,杨明建,刘建成,赵葵.高LET的~7Li离子致DNA损伤的直接和间接作用研究[J].核技术,2007(04):250-254. DOI：

SUI Li1 GUO Jiyu1 KONG Fuquan1 NI Meinan1 CAI Minghui1, 2 YANG Mingjian1, 2 LIU Jiancheng1 ZHAO Kui1, et al. Investigation of direct and indirect interaction of DNA damage induced by high LET ~7Li ions[J]. Nuclear techniques, 2007, (4): 250-254. DOI：

摘要

在HI-13串列加速器加速的具有高LET值的7Li离子辐照不同浓度的pUC19质粒DNA水溶液、加自由基清除剂（甘露醇）的DNA水溶液以及干状DNA样品

利用高分辨的原子力显微镜技术

研究7Li致DNA损伤的直接作用和间接作用。结果显示

在相同剂量下

7Li离子比低LET辐射能诱发更多的双链断裂

形成更多的集团损伤

使DSB的分布更局部和更密集。对于水溶液DNA

7Li离子的水辐解产生的自由基的间接作用在DNA分子链断裂的产生方面发挥着重要作用

而且自由基清除剂甘露醇能有效地保护DNA分子。

Abstract

In order to investigate the direct and indirect interaction of DNA damage induced by high LET heavy ions as well as the protective function of scavenger by means of atomic force microscopy

samples of pUC19 plasmid DNA aqueous solution

pUC19 plasmid DNA aqueous solution with scavenger(mannitol) and dry DNA are irradiated by 7Li ions from the HI-13 Tandem accelerator in China Institute of Atomic Energy(CIAE). Results show that the indirect interaction of free radical plays an important role in DNA strand break induced by 7Li ions and mannitol can protect the DNA molecules effectively.

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Related Institution

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China Institute of Atomic Energy, Beijing 102413, China) 2

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