Studies on elemental components and cytotoxicity of water-soluble constituents in PM<sub>2.5</sub> collected in Wusong Industrial Area

CHENG Shuo WANG Wei TAN Mingguang CHEN Jianmin ZHANG Guilin LI Yan

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Studies on elemental components and cytotoxicity of water-soluble constituents in PM_2.5 collected in Wusong Industrial Area

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- Studies on elemental components and cytotoxicity of water-soluble constituents in PM_2.5 collected in Wusong Industrial Area
- NUCLEAR TECHNIQUES Issue 3, (2006)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所
  2. 中国科学院上海应用物理研究所,上海,201800
- 作者简介：
- 基金信息：
  
  中国科学院知识创新工程项目(KJCXZ-SN-NO1);国家基金委十五重大项目;上海市自然科学基金项目(O3ZR14111)
- DOI：
  CLC： X51
- Published：01 March 2006
- 稿件说明：
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[1]程硕,王伟,谈明光,陈建敏,张桂林,李燕.上海市吴淞工业区大气PM_(2.5)水溶成分的元素分析及细胞毒性研究[J].核技术,2006(03):182-188.

CHENG Shuo WANG Wei TAN Mingguang CHEN Jianmin ZHANG Guilin LI Yan. Studies on elemental components and cytotoxicity of water-soluble constituents in PM_2.5 collected in Wusong Industrial Area[J]. Nuclear techniques, 2006, (3): 182-188.
[1]程硕,王伟,谈明光,陈建敏,张桂林,李燕.上海市吴淞工业区大气PM_(2.5)水溶成分的元素分析及细胞毒性研究[J].核技术,2006(03):182-188. DOI：

CHENG Shuo WANG Wei TAN Mingguang CHEN Jianmin ZHANG Guilin LI Yan. Studies on elemental components and cytotoxicity of water-soluble constituents in PM_2.5 collected in Wusong Industrial Area[J]. Nuclear techniques, 2006, (3): 182-188. DOI：

摘要

通过ICP-MS测定了上海市吴淞地区大气PM2.5水溶成分金属元素含量

通过四唑盐（MTT）测定细胞存活率

通过超氧化歧化酶（SOD）和丙二醛（MDA）两个指标测定细胞氧化损伤

琼脂糖凝胶电泳测定细胞内DNA损伤

流式细胞仪（Flowcytometry）检测细胞凋亡和周期等实验研究了大气PM2.5水溶成分的细胞毒性。实验结果表明:PM2.5可溶成分中Zn元素含量最高

PM2.5在一定浓度范围内能导致细胞死亡

引起细胞的氧化损伤

影响DNA的复制

阻碍细胞增殖

但没有诱导细胞凋亡。PM2.5中可溶金属离子对细胞毒性表现为联合作用。

Abstract

The elemental concentration of water-soluble component of PM2.5 collected in Wusong Industrial Area

Shanghai was measured by ICP-MS. Studies on the cytotoxicities of such component were carried out. The rate of cell proliferation was detected by MTT assay. Both SOD and MDA assays were adopted for assessing the ability to cause cell oxidative damage. Agar gel electrophoresis and FCM were used to examine the cellular DNA damage. The results show that the water-soluble metal with the highest concentration in PM2.5 is zinc. Our data demonstrate that the water-soluble component of PM2.5 can mediate cell proliferation

cause cell oxidative damage and attenuate the cell DNA synthesis

but can not cause cell apoptosis action. In conclusion

these water soluble metal ions in PM2.5 displayed the synergic effects.

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Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800,China) 2

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Studies on elemental components and cytotoxicity of water-soluble constituents in PM2.5 collected in Wusong Industrial Area

DOI：

摘要

Abstract

关键词

Keywords

references

Studies on elemental components and cytotoxicity of water-soluble constituents in PM_2.5 collected in Wusong Industrial Area