Study of quantitative method of hepatic function with hepatobiliary imaging by SPECT

CHENG Muhua PAN Zhiheng LING Yunbiao ZHANG Feng CHEN Weizhen

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Study of quantitative method of hepatic function with hepatobiliary imaging by SPECT

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- Study of quantitative method of hepatic function with hepatobiliary imaging by SPECT
- NUCLEAR TECHNIQUES Issue 4, (2006)
- 作者机构：
  
  1. 中山大学附属第三医院
  2. 中山大学附属第三医院,广州,510630
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817.4
- Published：01 April 2006
- 稿件说明：
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[1]程木华,潘志恒,凌云彪,张峰,陈维真.用肝胆显像定量分析方法评价肝细胞功能的探讨[J].核技术,2006(04):276-278.

CHENG Muhua PAN Zhiheng LING Yunbiao ZHANG Feng CHEN Weizhen. Study of quantitative method of hepatic function with hepatobiliary imaging by SPECT[J]. Nuclear techniques, 2006, (4): 276-278.
[1]程木华,潘志恒,凌云彪,张峰,陈维真.用肝胆显像定量分析方法评价肝细胞功能的探讨[J].核技术,2006(04):276-278. DOI：

CHENG Muhua PAN Zhiheng LING Yunbiao ZHANG Feng CHEN Weizhen. Study of quantitative method of hepatic function with hepatobiliary imaging by SPECT[J]. Nuclear techniques, 2006, (4): 276-278. DOI：

摘要

对用肝胆显像定量分析方法评价肝硬化患者的肝细胞功能变化进行探讨。对37例肝硬化患者及12例正常对照组

进行肝胆动态显像。通过三室模型运算

去除肝血池、胆道放射性活度

获得肝细胞摄取、排泄功能的放射性活度-时间曲线

并计算肝细胞摄取和排泄等功能指标。通过三室模型运算可获得肝细胞的代谢曲线

应用于临床研究显示肝硬化组高峰时间、平均残存指数均显著高于正常对照组

P<0.01。肝硬化组与正常组比较高峰值摄取指数、摄取斜率、排泄斜率均显著降低

P<0.05。总之

肝胆显像定量分析是一种灵敏评价肝细胞代谢功能变化的无创性方法

可用于分析肝硬化患者肝细胞代谢功能变化。

Abstract

The purpose of this paper is to study the quantitative method of evaluating hepatic function of patients with hepatocirrhosis. The 37 cases of hepatocirrhosis and the 12 controls were arranged to perform the hepatobiliary dynamic imaging with 99mTc-labelled ethylene hepatobiliary iminodiacetic acid (99mTc-EHIDA). Based on the three compartmental model

we acquired the radioactivity-time curves of the liver cell

and calculated the function indexes of liver cell’s uptake and excretion. The peak time and mean residue index for the hepatocirrhosis group were higher than those for the normal controls

P< 0.01. Compared to normal controls

the peak value

index of uptake

uptake slope and excretion slope of the time–activity curves for the hepatocirrhosis group were all lower

P<0.05. Hence the quantitative evaluation of hepatobiliary imaging was a better method for evaluating the change of liver cell functions of hepatocirrhosis.

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Related Author

CHENG Muhua LING Yunbiao PAN Zhiheng ZHANG Feng CHEN Weizhen

凌云彪

潘志恒

张峰

陈维真

Related Institution

The Third Affiliated Hospital of Sen Yat-Sen University of Medical Science

中山医科大学附属第三医院

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