Mutagenic effects of avilamycin-producing strain induced by N+ ion implantation have been investigated. The experimental results indicated that the survival rate curve took a "saddle" shape and the unique mutation effects of N+ ion implantation were presented. To obtain high-yield avilamycin-producing strain

the ion implantation dose of 5×1015 cm-2（the mutation rate was 20.9%-26.2%） was used and screening of streptomycin-resistant mutant was done in the study on breeding mutation. The SVN-116 mutant was obtained

with an avilamycin yield of 79.6-82.9 mg·L-1 that was 1.414-1.472 times as much as the original strain.