The new bone-imaging agent: Preparation and biodistribution of <sup>99</sup>Tc<sup>m</sup>-ZL

WANG Hongyong1; 2 LUO Shineng1; 2 XIE Minhao1 LIU Xiaoya2 FENG Yingying1 CHEN Zhiming1 YE Wanzhong1 1

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The new bone-imaging agent: Preparation and biodistribution of ⁹⁹Tc^m-ZL

更新时间：2021-03-12

- The new bone-imaging agent: Preparation and biodistribution of ⁹⁹Tc^m-ZL
- NUCLEAR TECHNIQUES Issue 6, (2006)
- 作者机构：
  
  1. 江苏省原子医学研究所
  2. 江南大学化学与材料工程学院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817
- Published：01 June 2006
- 稿件说明：
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[1]王洪勇,罗世能,谢敏浩,刘晓亚,冯瑛瑛,陈志明,叶万忠.新型骨显像剂~(99)Tc~m-ZL的制备和动物实验研究[J].核技术,2006(06):438-441.

WANG Hongyong1, 2 LUO Shineng1, 2 XIE Minhao1 LIU Xiaoya2 FENG Yingying1 CHEN Zhiming1 YE Wanzhong1 1. The new bone-imaging agent: Preparation and biodistribution of ⁹⁹Tc^m-ZL[J]. Nuclear techniques, 2006, (6): 438-441.
[1]王洪勇,罗世能,谢敏浩,刘晓亚,冯瑛瑛,陈志明,叶万忠.新型骨显像剂~(99)Tc~m-ZL的制备和动物实验研究[J].核技术,2006(06):438-441. DOI：

WANG Hongyong1, 2 LUO Shineng1, 2 XIE Minhao1 LIU Xiaoya2 FENG Yingying1 CHEN Zhiming1 YE Wanzhong1 1. The new bone-imaging agent: Preparation and biodistribution of ⁹⁹Tc^m-ZL[J]. Nuclear techniques, 2006, (6): 438-441. DOI：

摘要

以氯化亚锡为还原剂、用Tcm标记唑来膦酸（ZL）制得Tcm-ZL

研究了SnCl22H2O和ZL的用量以9999˙及溶液pH对标记率的影响

在pH=3—9、ZL的用量大于2mg和SnCl22H2O的用量大于40μg时

室温反应˙8min

可获放化纯和标记率大于90%的Tcm-ZL

标记后6h内放化纯度保持不变。并对Tcm-ZL的小鼠体9999内分布和兔显像进行了研究。小鼠体内生物分布表明

静脉注射后30min时

骨摄取达13.45%ID/g

am骨肌/和am骨/血分别达到28.01和16.96;兔显像表明

静脉注射75min后

即可获得清晰的骨显像。研究表明

99Tcm-ZL是一种稳定性好、制备简便、值得进一步深入研究的骨显像剂。

Abstract

The Tcm labeled zoledronate (99Tcm-ZL) was prepared by the reduction of Na99TcmO4 with SnCl2 2H2O. 99 ˙ The effect of the amounts of SnCl2 2H2O and ZL

and pH value on the labeling yield and radiochemical purity of ˙ 99Tcm-ZL were investigated. When the amounts of SnCl2 2H2O and ZL were more than 40 μg and 2mg

respectively

˙ the pH value was between 3 and 9

and the labeling reaction continued for 8min at room temperature

both labeling yield and radiochemical purity of Tcm-ZL were over 90%. The biodistribution in mice and bone scan in rabbit of 99 99Tcm-ZL were also studied. The results show that at 30min after injection of Tcm-ZL

the uptake in bone was up to 99 13.45%ID/g

bone-to-muscle and bone-to-blood uptake ratios were 28.01 and 16.96

respectively. The clear bone-imaging was obtained at 75min after injection of Tcm-ZL. So Tcm-ZL was a potential bone-imaging agent. 99 99

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Related Institution

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The new bone-imaging agent: Preparation and biodistribution of 99Tcm-ZL

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摘要

Abstract

关键词

Keywords

references

The new bone-imaging agent: Preparation and biodistribution of ⁹⁹Tc^m-ZL