Diagnostic value of <sup>99</sup>Tc<sup>m</sup>-N-NOET imaging for intracranial occupying lesion

ZHANG Ying1 LIU Jianzhong1 LI Sijin1 FAN Yimin2 ZHANG Wei1 HU Guang1 1

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Diagnostic value of ⁹⁹Tc^m-N-NOET imaging for intracranial occupying lesion

更新时间：2021-03-12

- Diagnostic value of ⁹⁹Tc^m-N-NOET imaging for intracranial occupying lesion
- NUCLEAR TECHNIQUES Issue 9, (2006)
- 作者机构：
  
  1. 山西医科大学第一医院核医学科
  2. 山西医科大学第一医院神经外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817.4
- Published：01 September 2006
- 稿件说明：
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[1]张莺,刘建中,李思进,范毅民,张薇,胡光.~(99)Tc~m-N-NOET脑显像在颅内占位病变鉴别诊断中的应用[J].核技术,2006(09):694-697.

ZHANG Ying1 LIU Jianzhong1 LI Sijin1 FAN Yimin2 ZHANG Wei1 HU Guang1 1. Diagnostic value of ⁹⁹Tc^m-N-NOET imaging for intracranial occupying lesion[J]. Nuclear techniques, 2006, (9): 694-697.
[1]张莺,刘建中,李思进,范毅民,张薇,胡光.~(99)Tc~m-N-NOET脑显像在颅内占位病变鉴别诊断中的应用[J].核技术,2006(09):694-697. DOI：

ZHANG Ying1 LIU Jianzhong1 LI Sijin1 FAN Yimin2 ZHANG Wei1 HU Guang1 1. Diagnostic value of ⁹⁹Tc^m-N-NOET imaging for intracranial occupying lesion[J]. Nuclear techniques, 2006, (9): 694-697. DOI：

摘要

将24例术前CT和或MRI发现颅内占位病变的患者进行了99Tcm-N-NOET脑显像

其中20例在次日进行了99Tcm-MIBI对照检查。所有患者于显像后2周内进行了手术。静脉注射显像剂后30min和2h采集图像

将显像结果进行4分法评分及计算机半定量分析计算肿瘤组织计数与正常脑组织比值（T/N）即摄取比值。两种显像剂在判断病变良恶性方面均有统计学差异

但二者之间无统计学差异。99Tcm-N-NOET可以通过血脑屏障

故它在脑肿瘤中的聚集不依赖于血脑屏障的破坏;肿瘤细胞增殖活跃的颅内病变可以聚集99Tcm-N-NOET

有助于对脑肿瘤治疗方式的选择和对预后估计;在颅内占位良性病变中

99Tcm-N-NOET很少有浓聚。

Abstract

The objectives of this study are to estimate the utility of NOET in the diagnosis of intracranial occupying lesion and to compare the detectability of NOET and MIBI and the relationship with histopathology. 24 patients with untreated intracranial occupying lesion confirmed by CT and/or MRI were included in this study. 20 of them underwent MIBI imaging also. All patients were operated during 2 weeks after imaging. Statistical significance was observed for both agents in differentiating intracranial occupying lesions

but no statistical significance between them. These preliminary results indicate that NOET can go through blood brain barrier and be concentrated on malignant lesions

but it is few concentrated on benign lesions and the false positive cases are less than MIBI. So it may be a more suitable new tumor positive agent.

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NIU Guosai1

2 LUO Shineng2

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Related Institution

Department of Nuclear Medicine,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University

Department of Thoracic Surgery,Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University

School of Chemical and material Engineering, Southern Yangtze University, Wuxi 214122,China) 2

江苏省原子医学研究所卫生部核医学重点实验室

Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040) 2

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Diagnostic value of 99Tcm-N-NOET imaging for intracranial occupying lesion

DOI：

摘要

Abstract

关键词

Keywords

references

Diagnostic value of ⁹⁹Tc^m-N-NOET imaging for intracranial occupying lesion