Efficiently automated synthesis of 2-[<sup>18</sup>F]-fluoro-2-deoxy-D-glucose

TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 GUO Xiaojun1 1

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Efficiently automated synthesis of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose

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- Efficiently automated synthesis of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose
- NUCLEAR TECHNIQUES Issue 7, (2006)
- 作者机构：
  
  1. 南方医科大学南方医院核医学科PET中心
  2. 华南农业大学理学院
- 作者简介：
- 基金信息：
  
  广东省科技计划资助项目(2003C34304);第一军医大学南方医院院长基金资助项目(991015)
- DOI：
  CLC： TQ28
- Published：01 July 2006
- 稿件说明：
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[1]唐刚华,唐小兰,王明芳,郭晓君.高产率自动化合成2-~(18)F-2-脱氧-D-葡萄糖[J].核技术,2006(07):531-536.

TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 GUO Xiaojun1 1. Efficiently automated synthesis of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose[J]. Nuclear techniques, 2006, (7): 531-536.
[1]唐刚华,唐小兰,王明芳,郭晓君.高产率自动化合成2-~(18)F-2-脱氧-D-葡萄糖[J].核技术,2006(07):531-536. DOI：

TANG Ganghua1 TANG Xiaolan2 WANG Mingfang1 GUO Xiaojun1 1. Efficiently automated synthesis of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose[J]. Nuclear techniques, 2006, (7): 531-536. DOI：

摘要

研究了2-18F-2-脱氧-D-葡萄糖（18F-FDG）的高产率自动化合成工艺。以三氟甘露糖为前体

采用“一锅法”和TRACERlabFXF-N自动化合成装置

在同一反应瓶中进行亲核氟化、氢氧化钠水解两步反应

然后用小柱中和分离纯化制备了F-FDG注射液。F-FDG的总合成时间约24min

未经校正的放化产率约为60%

1818放化纯度大于99%。采用改进了的自动化工艺合成F-FDG注射液

操作简便

可望成为F-FDG较为实用1818的合成方法。

Abstract

Automated synthetic technology of 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) was described. Automated synthesis of F-FDG was performed by “one-pot” and “two-step reaction” procedures in TRACERlab 18 FXF-N system. 18F-FDG injection was obtained via “two-step reaction” including nucleophilic fluorination of the precursor 1

6-tetra-O-acetyl-2-O-trifluoromethanesulfony-β-D-mannopyranose with F-fluoride and hydrolysis 18 with NaOH in the same reaction vessel

and subsequently purificated with Sep-Pak cartridges. The uncorrected radiochemical yield of 18F-FDG was about 60% and radiochemical purity was more than 99% within the total synthesis time about 24 min. Improved synthesis method of F-FDG injection is simple to operate and can become a 18 practical method of preparation.

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Related Institution

School of Chemical Engineering and Light Industry, Guangdong University of Technology

Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University

PET Center,No.2 Hospital Affiliated to College of Medicine,Zhejiang University

PET Centre, Department of Nuclear Medicine, Nan Fang Hospital, Southern Medical University

PET Center Huashan Hospital, Fudan University, Shanghai 200235) 2

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Efficiently automated synthesis of 2-[18F]-fluoro-2-deoxy-D-glucose

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摘要

Abstract

关键词

Keywords

references

Efficiently automated synthesis of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose