Chirality plays important roles in radiopharmaceuticals

SHEN Yumei

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Chirality plays important roles in radiopharmaceuticals

更新时间：2021-03-12

- Chirality plays important roles in radiopharmaceuticals
- NUCLEAR TECHNIQUES Issue 7, (2006)
- 作者机构：
  
  中国科学院上海应用物理研究所,上海,201800
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817
- Published：01 July 2006
- 稿件说明：
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[1]沈玉梅.手性在放射性药物中的作用[J].核技术,2006(07):518-521.

SHEN Yumei. Chirality plays important roles in radiopharmaceuticals[J]. Nuclear techniques, 2006, (7): 518-521.
[1]沈玉梅.手性在放射性药物中的作用[J].核技术,2006(07):518-521. DOI：

SHEN Yumei. Chirality plays important roles in radiopharmaceuticals[J]. Nuclear techniques, 2006, (7): 518-521. DOI：

摘要

本文简要介绍了手性、靶向性的基本概念以及手性与靶向性的关系。在放射性药物研发中如果放射性核素标记的药物分子中含有不对称因素

必须将两个对映异构体分开

否则它的靶向性不会好。手性是研究受体放射性药物构效关系时必须考虑的因素之一。

Abstract

The paper introduces the basic concept of chirality

target specific selectivity and their relationship in radiopharmaceuticals. If the ligands labeled by radionuclides have chiral centers

the enantiomers must be separated

or the target specific selectivity will not be good. Chirality is one of the most important factors which must be considered in the study of the structure-activity relationship of radiopharmaceuticals.

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Related Author

程建平

李君利

SUN Liang LI Junli CHENG Jianping

沈玉梅

成康民

冯翠兰

WANG Mouhua FENG Cuilan CHENG Kangmin SHEN Yumei

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Related Institution

Department of Engineering Physics, Tsinghua University

清华大学工程物理系

中国科学院上海应用物理研究所

School of Pharmacy, Fudan University

复旦大学药学院

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