Study on the whole body distribution of <sup>99</sup>Tc<sup>m</sup>-angiostatin and its effect on novel blood vessel

TAO Yonghui1 ZHANG Lianfen1 YOU Xuyang2 WAN Weixing2 JIN Jian1 1

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Study on the whole body distribution of ⁹⁹Tc^m-angiostatin and its effect on novel blood vessel

更新时间：2021-03-12

- Study on the whole body distribution of ⁹⁹Tc^m-angiostatin and its effect on novel blood vessel
- NUCLEAR TECHNIQUES Issue 9, (2006)
- 作者机构：
  
  1. 江南大学工业生物技术教育部重点实验室
  2. 苏州大学附属第四医院
- 作者简介：
- 基金信息：
  
  江苏省自然科学基金项目(BK2002071)
- DOI：
  CLC： R817
- Published：01 September 2006
- 稿件说明：
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[1]陶永辉,张莲芬,尤徐阳,万卫星,金坚.~(99)Tc~m-angiostatin的体内分布及其与新生血管作用的实验研究[J].核技术,2006(09):690-693.

TAO Yonghui1 ZHANG Lianfen1 YOU Xuyang2 WAN Weixing2 JIN Jian1 1. Study on the whole body distribution of ⁹⁹Tc^m-angiostatin and its effect on novel blood vessel[J]. Nuclear techniques, 2006, (9): 690-693.
[1]陶永辉,张莲芬,尤徐阳,万卫星,金坚.~(99)Tc~m-angiostatin的体内分布及其与新生血管作用的实验研究[J].核技术,2006(09):690-693. DOI：

TAO Yonghui1 ZHANG Lianfen1 YOU Xuyang2 WAN Weixing2 JIN Jian1 1. Study on the whole body distribution of ⁹⁹Tc^m-angiostatin and its effect on novel blood vessel[J]. Nuclear techniques, 2006, (9): 690-693. DOI：

摘要

本文研究血管抑素（Angiostatin

AS）对血管内皮细胞作用的特异性。采用SnCl2还原法制备99Tcm-rhAS

通过鼠尾静脉注射99Tcm-rhAS

观察其体内分布并在小鼠S180肿瘤和Matrigel模型上进行显像及放射自显影

研究AS对新生血管的作用特异性。结果显示

99Tcm-rhAS在体内通过肝、肾进行代谢;S180肿瘤和Matrigel均可特异性摄取99Tcm-rhAS。S180肿瘤及Matrigel模型对99Tcm-rhAS特异性摄取表明AS可与新生血管特异性结合

其抑制肿瘤的作用是基于靶向血管内皮细胞的。

Abstract

The specificity of action of angiostatin on vascular endothelial cell is studied. 99Tcm-angiostatin was prepared by the SnCl2 reduced approach

then injected into the mice bearing S180 tumor or Matrigel via tail vein. The whole body distribution and the effect of 99Tcm-angiostatin in vivo were observed on the model of mice bearing S180 tumor and Matrigel by imaging and radioautography. The resultes indicate that the metabolism of 99Tcm-angiostatin is realized mainly by the liver and kidney pathway

and both S180 tumor and Matrigel can specifically uptake 99Tcm-angiostatin. The angiostatin’s role of inhibiting tumor is found on the basis of targeting novel vascular endothelial cell.

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Key Laboratory of Radiation Physics and Technology, Education Ministry of China, Institute of Nuclear Science and Technology, Sichuan University

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Study on the whole body distribution of 99Tcm-angiostatin and its effect on novel blood vessel

DOI：

摘要

Abstract

关键词

Keywords

references

Study on the whole body distribution of ⁹⁹Tc^m-angiostatin and its effect on novel blood vessel