The preparation of <sup>188</sup>Re-AEDP

LI Qingnuan  1  ZHANG Xiuaodong  1  SHENG Rong  2  LI Wenxin  1  1

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The preparation of ¹⁸⁸Re-AEDP

更新时间：2021-03-12

- The preparation of ¹⁸⁸Re-AEDP
- NUCLEAR TECHNIQUES Issue 1, (2001)
- 作者机构：
  
  1. 中国科学院上海原子核研究所
  2. 中国科学院上海原子核研究所,上海,201800
- 作者简介：
- 基金信息：
  
  国家自然科学基金!(2 96 710 33);国家攀登B资助
- DOI：
  CLC： R730.4
- Published：01 January 2001
- 稿件说明：
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[1]李晴暖,张晓东,盛荣,李文新.~(188)Re-AEDP的标记条件研究[J].核技术,2001(01):76-80.

LI Qingnuan 1 ZHANG Xiuaodong 1 SHENG Rong 2 LI Wenxin 1 1. The preparation of ¹⁸⁸Re-AEDP[J]. Nuclear techniques, 2001, (1): 76-80.
[1]李晴暖,张晓东,盛荣,李文新.~(188)Re-AEDP的标记条件研究[J].核技术,2001(01):76-80. DOI：

LI Qingnuan 1 ZHANG Xiuaodong 1 SHENG Rong 2 LI Wenxin 1 1. The preparation of ¹⁸⁸Re-AEDP[J]. Nuclear techniques, 2001, (1): 76-80. DOI：

摘要

用18 8 W / 188Re发生器淋洗得到的188Re研制具有潜在临床应用价值的骨疼痛治疗剂188Re -AEDP。研究了在不同配体用量、亚锡含量和 pH条件下

载体用量对标记率和稳定性的影响。实验结果表明 :在最佳条件（pH1.10

AEDP 2 0mg/mL

氯化亚锡 2mg/mL

抗坏血酸 3mg/mL）下

用无载体188Re标记的188Re -AEDP的标记率为 90 %— 93% ;标记后调 pH为 6

2 4h后放化纯度为70 % ;而用含一定量载体的188Re标记的标记率为 95%— 98%

标记 2 4h后放化纯度为 93%。

Abstract

A rhenium-AEDP(1-amino-ethylene diphosphonic acid) compound was synthesized by using 188 Re eluted from the 188 W/ 188 Re generator. Stannous chloride was used as the reducing agent for the reduction of the rhenium. Dependence of the labeling yield of 188 Re-AEDP upon concentrations of reducing agent and AEDP

pH and the carrier added was examined. Under optimum conditions

the labeling yields of 188 Re-AEDP were 90%—93% using carrier-free 188 Re and 95%—98% using carrier-added 188 Re respectively. The stability of 188 Re-AEDP at pH≈6 was studied. It was found that carrier had significant effect on the stability of 188 Re-AEDP.

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Related Author

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SHENG Rong

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LI Qingnuan

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Related Institution

上海科兴药业公司

浙江大学湖滨校区药学院

Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences

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Division of Ionizing Radiation, National Institute of Metrology

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The preparation of 188Re-AEDP

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摘要

Abstract

关键词

Keywords

references

The preparation of ¹⁸⁸Re-AEDP