The influence of iodine and selenium supplementation on trace   elemental contents in erythrocyte of the cretinism rats

LIU Nianqing  LIU Pingsheng

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The influence of iodine and selenium supplementation on trace elemental contents in erythrocyte of the cretinism rats

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- The influence of iodine and selenium supplementation on trace elemental contents in erythrocyte of the cretinism rats
- NUCLEAR TECHNIQUES Issue 3, (2001)
- 作者机构：
  
  1. 中国科学院高能物理研究所,北京,100080
  2. 中国医学科学院协和医科大学!北京协和医院北京,100730
- 作者简介：
- 基金信息：
  
  国家自然科学基金! (19975 0 5 5 );中国科学院核技术开放实验室资助
- DOI：
  CLC： R581.21
- Published：01 March 2001
- 稿件说明：
移动端阅览
[1]刘年庆,刘平生,朱立,赵志英,王正华,李彦芬.补碘和硒对克汀鼠红血球中的微量元素的影响[J].核技术,2001(03):189-193.

LIU Nianqing LIU Pingsheng. The influence of iodine and selenium supplementation on trace elemental contents in erythrocyte of the cretinism rats[J]. Nuclear techniques, 2001, (3): 189-193.
[1]刘年庆,刘平生,朱立,赵志英,王正华,李彦芬.补碘和硒对克汀鼠红血球中的微量元素的影响[J].核技术,2001(03):189-193. DOI：

LIU Nianqing LIU Pingsheng. The influence of iodine and selenium supplementation on trace elemental contents in erythrocyte of the cretinism rats[J]. Nuclear techniques, 2001, (3): 189-193. DOI：

摘要

用克汀病流行病区的粮食喂养大鼠（克汀鼠）

分成 4个组补硒、补碘、补碘同时补硒、和作为对照的低碘鼠

另取一正常对照组。补充 5周后

用PIXE法和XRF法测量它们红血球的微量元素（K、Ca、Mn、Fe、Cr、Cu、Zn、Rb、Pb等）。用放射性免疫法测定甲状腺激素指标（T3、T4、FT3、FT4、rT3等）。获得的数据用SPSS/PC单因素方差分析和相关性检验。结果表明

低碘鼠补碘、硒或同时补碘硒后

Zn、Mn、Cu和Rb的含量变化以及甲状腺激素指标T4、FT4和rT3比低碘鼠显著地升高。

Abstract

The contents of K

Rb and Pb in the erythrocyte of 5 groups of rats

were measured by PIXE and XRF. Four groups of the cretinism rats were continuously fed the feed from epidemic cretinism area. Three groups among them drank the water with I and/or Se supplementation. Control group was normal rats fed normal feed. Five weeks later the blood samples were collected. The erythrocyte was separated for the determination of elemental concentrations

the serum for the radioimmunoassay of thyroid hormones T3

FT3

FT4 and rT3 status. The comparison among five groups and the correlation between elements and thyroid hormones were performed by using SPSS/PC statistical package. The results showed that comparing with non-supplementation or control groups the concentrations of Zn

or Rb in the groups of I and/or Se supplementation were significantly fluctuating

while thyroid hormones T4

FT4 and rT3 significantly increased.

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