Preparation of <sup>188</sup>Re-MAG<sub>3</sub> and in vivo evaluation in mice

JIA Bing ZHAO Huiyun DU Jin WANG Fan1

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Preparation of ¹⁸⁸Re-MAG₃ and in vivo evaluation in mice

更新时间：2021-03-12

- Preparation of ¹⁸⁸Re-MAG₃ and in vivo evaluation in mice
- NUCLEAR TECHNIQUES Issue 1, (2004)
- 作者机构：
  
  1. 北京大学医学同位素研究中心
  2. 北京大学医学同位素研究中心北京 100083 中国原子能科学研究院同位素研究所,北京,102413
  3. ,北京,100083
- 作者简介：
- 基金信息：
  
  北京大学“985”资助项目
- DOI：
  CLC： R817
- Published：01 January 2004
- 稿件说明：
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[1]贾兵,赵慧云,杜进,王凡.~(188)Re-MAG_3的制备及动物体内评价[J].核技术,2004(01):57-61.

JIA Bing ZHAO Huiyun DU Jin WANG Fan1. Preparation of ¹⁸⁸Re-MAG₃ and in vivo evaluation in mice[J]. Nuclear techniques, 2004, (1): 57-61.
[1]贾兵,赵慧云,杜进,王凡.~(188)Re-MAG_3的制备及动物体内评价[J].核技术,2004(01):57-61. DOI：

JIA Bing ZHAO Huiyun DU Jin WANG Fan1. Preparation of ¹⁸⁸Re-MAG₃ and in vivo evaluation in mice[J]. Nuclear techniques, 2004, (1): 57-61. DOI：

摘要

本工作着重研究了可用于PTCA（Percutaneous transluminal coronary angioplasty）后冠状动脉再狭窄防治的放射性标记化合物188Re-MAG3的制备

并与Na188ReO4的小鼠体内生物分布加以比较。结果表明

在TechneScan MAG3锝药盒中加入酒石酸亚锡

控制标记条件

188Re-MAG3的标记率可大于98％。188Re-MAG3在小鼠体内的血液清除明显快于Na188ReO4

甲状腺和胃肠道吸收明显低于Na188ReO

标记物主要经肾脏通过尿液排出体外。为降低PTCA后冠脉再狭窄的发生率

与Na188ReO4相比

188Re-MAG3更适于临床应用。

Abstract

188Re-MAG3

a potential radiopharmaceutical for restenosis treatment after PTCA

was prepared with commercially available TechneScan MAG3 kit. The labeling yield of 188Re-MAG3 was more than 98 % under the optimal labeling condition. The data revealed that stability of 188Re-MAG3 in reaction medium and in saline was better than in bovine serum. Compared to Na188ReO4

the blood clearance of 188Re-MAG3 was faster and the uptake in thyroid and stomach was lower. The radiolabeled compound was excreted rapidly through urinary system.188Re-MAG3 is promising for clinical trial instead of Na188ReO4.

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Related Institution

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Shanghai Institute of Applied Physics, China Academy of Sciences, Shanghai 201800, China) 2

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Preparation of 188Re-MAG3 and in vivo evaluation in mice

DOI：

摘要

Abstract

关键词

Keywords

references

Preparation of ¹⁸⁸Re-MAG₃ and in vivo evaluation in mice