Biodistribution of <sup>188</sup>Re-AEDP in rats and its dependence on rhenium carrier

LI Qingnuan; ZHANG Xiaodong; SHENG Rong; MING Xiaofeng XU Jianying; HU Weiqing; LI Wenxin

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Biodistribution of ¹⁸⁸Re-AEDP in rats and its dependence on rhenium carrier

更新时间：2021-03-12

- Biodistribution of ¹⁸⁸Re-AEDP in rats and its dependence on rhenium carrier
- NUCLEAR TECHNIQUES Issue 11, (2000)
- 作者机构：
  
  1. 中国科学院上海原子核研究所,上海,201800
  2. 浙江大学湖滨校区药学院,杭州,310031
  3. 上海科兴药业公司,上海,201800
- 作者简介：
- 基金信息：
  
  国家自然科学基金!（29671033）;攀登B项目资助
- DOI：
  CLC：
- Published：01 November 2000
- 稿件说明：
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[1]李晴暖,张晓东,盛荣,闵小锋,须剑鹰,胡伟青,李文新.~(188)Re—AEDP在小鼠中的生物分布及其与载体的依赖关系[J].核技术,2000(11):757-761.

LI Qingnuan, ZHANG Xiaodong, SHENG Rong, et al. Biodistribution of ¹⁸⁸Re-AEDP in rats and its dependence on rhenium carrier[J]. Nuclear techniques, 2000, (11): 757-761.
[1]李晴暖,张晓东,盛荣,闵小锋,须剑鹰,胡伟青,李文新.~(188)Re—AEDP在小鼠中的生物分布及其与载体的依赖关系[J].核技术,2000(11):757-761. DOI：

LI Qingnuan, ZHANG Xiaodong, SHENG Rong, et al. Biodistribution of ¹⁸⁸Re-AEDP in rats and its dependence on rhenium carrier[J]. Nuclear techniques, 2000, (11): 757-761. DOI：

摘要

用１８８Ｗ／１８８Ｒｅ发生器淋洗得到的１８８Ｒｅ示踪剂分别制备了无载体和有载体的１８８Ｒｅ－ＡＥＤＰ（１－氨基－亚乙基－１，１－二膦酸），研究了这两种标记化合物在小鼠体内的分布，并讨论了载体对１８８Ｒｅ－ＡＥＤＰ生物分布的可能影响。实验结果指出：有载体的１８８Ｒｅ－ＡＥＤＰ有更高的骨摄取率和Ｔ／ＮＴ比，并且血液清除快，因而是一个有潜在价值的骨疼痛治疗剂。

Abstract

Carrier-free 188Re- and carrier-added 188Re-AEDP (1-amino-ethylene diphosphonic acid) were synthesized by using 188Re tracer eluted from 188W/188Re generator. The distributions of both 188Re-labelled compounds in rats were measured and the dependence of their biodistribution on the rhenium carrier was studied. The results showed much higher skeletal uptake

T/NT and more rapid blood clearance when using carrier-added 188Re. It was found that carrier has effect on the skeletal uptake of 188Re-AEDP. Thus 188Re-AEDP is a potential radiopharmaceutical which may be therapeutically beneficial to bone metastases.

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LI Qingnuan 1 ZHANG Xiuaodong 1 SHENG Rong 2 LI Wenxin 1 1

张晓东

盛荣

李文新

LI Jing1

2 ZHU Ying1 ZHANG Xiaoyong1

2 LI Wenxin1 HUANG Qing1 1

李文新

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Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) 2

中国科学院上海原子核研究所

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) 2

中国科学院研究生院

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Biodistribution of 188Re-AEDP in rats and its dependence on rhenium carrier

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摘要

Abstract

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Biodistribution of ¹⁸⁸Re-AEDP in rats and its dependence on rhenium carrier