Experimental studies on thrombus imaging with <sup>99m</sup>Tc-recombinant hirudin

ZHANG Rongjun; WAN Weixing; ZHOU Yan; TAN Chen; TAO Yonghui WANG Bochen; HAN Yumin; JIN Jian

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Experimental studies on thrombus imaging with ^99mTc-recombinant hirudin

更新时间：2021-03-12

- Experimental studies on thrombus imaging with ^99mTc-recombinant hirudin
- NUCLEAR TECHNIQUES Issue 11, (2000)
- 作者机构：
  
  核医学国家重点实验室!江苏省原子医学研究所无锡,214063
- 作者简介：
- 基金信息：
  
  卫生部科研基金资助!（96－1－344）
- DOI：
  CLC：
- Published：01 November 2000
- 稿件说明：
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[1]张荣军,万卫星,周彦,谭成,陶永辉,王博诚,韩玉珉,金坚.新型血栓显像剂～(99m)Tc-重组水蛭素的实验研究[J].核技术,2000(11):771-775.

ZHANG Rongjun, WAN Weixing, ZHOU Yan, et al. Experimental studies on thrombus imaging with ^99mTc-recombinant hirudin[J]. Nuclear techniques, 2000, (11): 771-775.
[1]张荣军,万卫星,周彦,谭成,陶永辉,王博诚,韩玉珉,金坚.新型血栓显像剂～(99m)Tc-重组水蛭素的实验研究[J].核技术,2000(11):771-775. DOI：

ZHANG Rongjun, WAN Weixing, ZHOU Yan, et al. Experimental studies on thrombus imaging with ^99mTc-recombinant hirudin[J]. Nuclear techniques, 2000, (11): 771-775. DOI：

摘要

采用直接法和间接法进行了９９ｍＴｃ标记重组水蛭素的研究，结果表明，间接法制备的９９ｍＴｃ－重组水蛙素具有更高的放化纯和稳定性。更适合于血栓模型的显像研究。９９ｍＴｃ－重组水蛙素在小鼠体内的分布表明，心、肝、脾、肺和脑的放射性分布均较低；放射性主要集中在肾脏，１５ｍｉｎ时肾脏放射性可达总注入剂量的６５％；且血液中放射性清除较快。兔血栓模型显像结果表明，９９ｍＴｃ－重组水蛙素可在血栓部位浓聚；注入后１ｈ即可使血栓清晰显影。因此，９９ｍＴｃ－重组水蛙素有望成为一种新型的血栓显像剂。

Abstract

Comparsion of two labeling methods showed that 99mTc-recombinant hirudin (99mTc-rH) prepared by modified 2-imiothiolane method had higher radiochemical purity and stability than that by direct labeling method. Biodistribution of 99mTc-rH in mice showed that the radioactivity in heart

lung

liver and spleen was very low

while that in kidney was high. 99mTc-rH was cleared rapidly in blood and excreted mostly from kidney. The arterial and venous thrombi in rabbits were clearly imaged 60min after injection of 99mTc-rH

T/B ratio was 2.24 and 1.95 respectively. The rH would be a potential agent for diagnosis of thrombotic disease.

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Related Author

万卫星

张荣军

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韩玉珉

金坚

谭成

张正毅

龚和禾

Related Institution

State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine

中国科学院生物物理研究所

Nanjing Medical Radioimmunoassay Center,Nanjing 210006)Gong Hehe

Zhang Zhengyi

南京市医学放射免疫检测中心南京市第一医院

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Experimental studies on thrombus imaging with 99mTc-recombinant hirudin

DOI：

摘要

Abstract

关键词

Keywords

references

Experimental studies on thrombus imaging with ^99mTc-recombinant hirudin