A study on preparation of curie-scale <sup>188</sup>W-<sup>188</sup>Re generator

YIN Duanzhi; HU Weiqing; SHI Xichang; CAO Benhong ZHOU Wei; YU Junfeng; WANG Yongxian; KNAPP F F

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A study on preparation of curie-scale ¹⁸⁸W-¹⁸⁸Re generator

更新时间：2021-03-12

- A study on preparation of curie-scale ¹⁸⁸W-¹⁸⁸Re generator
- NUCLEAR TECHNIQUES Issue 11, (2000)
- 作者机构：
  
  1. 中国科学院上海原子核研究所,上海,201800
  2. 上海科兴药业公司上海 201800,中国科学院上海原子核研究所,上海,201800
  3. 上海科兴药业公
- 作者简介：
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- DOI：
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- Published：01 November 2000
- 稿件说明：
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[1]尹端沚,胡伟青,施锡昌,曹本红,周伟,于俊峰,汪勇先,F.F.KNAPP.居里级的~(188)W—~(188)Re发生器的研制[J].核技术,2000(11):767-770.

YIN Duanzhi, HU Weiqing, SHI Xichang, et al. A study on preparation of curie-scale ¹⁸⁸W-¹⁸⁸Re generator[J]. Nuclear techniques, 2000, (11): 767-770.
[1]尹端沚,胡伟青,施锡昌,曹本红,周伟,于俊峰,汪勇先,F.F.KNAPP.居里级的~(188)W—~(188)Re发生器的研制[J].核技术,2000(11):767-770. DOI：

YIN Duanzhi, HU Weiqing, SHI Xichang, et al. A study on preparation of curie-scale ¹⁸⁸W-¹⁸⁸Re generator[J]. Nuclear techniques, 2000, (11): 767-770. DOI：

摘要

在逐步放大试验和钨装载量模拟试验的基础上，成功地制备了数个居里级的１８８Ｗ－１８８Ｒｅ发生器，１８８Ｗ的最大装载量达４０．７ＧＢｑ。１８８Ｒｅ的淋洗效率为９０％（１０ｍＬ淋洗体积），１８８Ｗ的漏穿为４×１０－７，得到的无载体的１８８Ｒｅ洗脱液核纯度＞９９．９％，放化纯度大于９９％，ｐＨ值为５，铝含量～１μｇ／ｍＬ，无菌、无热原符合药典要求，可用于制备各种１８８Ｒｅ标记的放射性治疗药物。

Abstract

A clinical-scale 188W-188Re generator loaded with more than one curie of 188W was successfully prepared. The yield of 188Re from generator eluted with 10mL isotonic saline solution was 90%. The breakthrough of 188W was 4 × 10-7. The purity of eluted 188Re was satisfactory. Radionuclide purity was >99.9%. Radiochemical purity was >99% of the 188Re as perrhenate ion. Concentration of aluminium in eluate was ～ 1 μ g Al/mL. The generator provides a convenient supply of sterile 188Re as sodium perrhenate in injectable saline solution ready for use in the preparation of 188Re labelled therapeutic reagents.

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A study on preparation of curie-scale 188W-188Re generator

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摘要

Abstract

关键词

Keywords

references

A study on preparation of curie-scale ¹⁸⁸W-¹⁸⁸Re generator