Preparation and imaging study of a hepatic receptor imaging agent

ZHANG Rongjun; LIANG Gaolin; WAN Weixing; CAI Gangming; YIE Wanzhong TAO Yonghui; ZHANG Lianfeng; TAN Cheng; JIN Jian

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Preparation and imaging study of a hepatic receptor imaging agent

更新时间：2021-03-12

- Preparation and imaging study of a hepatic receptor imaging agent
- NUCLEAR TECHNIQUES Issue 11, (2000)
- 作者机构：
  
  1. 核医学国家重点实验室
  2. 江苏省原子医学研究所
  3. 核医学国家重点实验室江苏省原子医学研究所!无锡214063江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 November 2000
- 稿件说明：
移动端阅览
[1]张荣军,梁高林,万卫星,蔡刚明,叶万忠,陶永辉,张莲芬,谭成,金坚.肝ASGP受体功能显像剂的制备及显像研究[J].核技术,2000(11):780-785.

ZHANG Rongjun, LIANG Gaolin, WAN Weixing, et al. Preparation and imaging study of a hepatic receptor imaging agent[J]. Nuclear techniques, 2000, (11): 780-785.
[1]张荣军,梁高林,万卫星,蔡刚明,叶万忠,陶永辉,张莲芬,谭成,金坚.肝ASGP受体功能显像剂的制备及显像研究[J].核技术,2000(11):780-785. DOI：

ZHANG Rongjun, LIANG Gaolin, WAN Weixing, et al. Preparation and imaging study of a hepatic receptor imaging agent[J]. Nuclear techniques, 2000, (11): 780-785. DOI：

摘要

采用ＦＰＬＣ快速纯化人血清白蛋白，利用双功能试剂２－亚胺基－２－甲氧基乙基－１－疏代－半乳糖甙与伯胺基的成脒反应，将硫代半乳糖残基引入人血清白蛋白分子，得到平均糖密度为３０的新半乳糖人血清白蛋白（ＮＧＡ）；用直接法制备９９ｍＴｃ－ＮＧＡ，其放化纯大于９０％，且室温下可稳定６ｈ以上，符合显像要求。９９ｍＴｃ－ＮＧＡ小鼠体内分布实验及大鼠、兔和狗的显像研究均表明９９ｍＴｃ－ＮＧＡ能够被肝脏特异摄取，且具有饱和性，主要通过胆道、肠道排泄，是一种较好的肝ＡＳＧＰ受体功能显像剂。

Abstract

Human serum albumin (HSA) was purified by FPLC with HiTrap Q column. Galactosyl neoglycoalbumin (NGA) was synthesized by the covalent coupling of a bifunctional reagent

2-imino-2-ethyloxymethyl- 1-thiogalactose

to HSA. The average number of galactose groups was 30 in each NGA. NGA was labeled directly with Na99mTcO4. The radiochemical purity of 99mTc-NGA was over 90%. Biodistribution in mice

liver imaging in rat

rabbit and dog all show that 99mTc-NGA is a good hepatic receptor imaging agent.

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