Autoradiographic Observation on distribution of <sup>99m</sup>Tc-MIBI in rat thyroid

DIAO Yao; XING Fuqin

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Autoradiographic Observation on distribution of ^99mTc-MIBI in rat thyroid

更新时间：2021-03-12

- Autoradiographic Observation on distribution of ^99mTc-MIBI in rat thyroid
- NUCLEAR TECHNIQUES Issue 11, (2000)
- 作者机构：
  
  中国医科大学同位素中心实验室,沈阳,110001
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- Published：01 November 2000
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[1]刁尧,邢福琴.应用放射自显影术观察~(99m)Tc-MIBI在大鼠甲状腺内的动态分布[J].核技术,2000(11):805-808.

DIAO Yao, XING Fuqin. Autoradiographic Observation on distribution of ^99mTc-MIBI in rat thyroid[J]. Nuclear techniques, 2000, (11): 805-808.
[1]刁尧,邢福琴.应用放射自显影术观察~(99m)Tc-MIBI在大鼠甲状腺内的动态分布[J].核技术,2000(11):805-808. DOI：

DIAO Yao, XING Fuqin. Autoradiographic Observation on distribution of ^99mTc-MIBI in rat thyroid[J]. Nuclear techniques, 2000, (11): 805-808. DOI：

摘要

报道了９９ｍＴｃ－ＭＩＢＩ在大鼠甲状腺内的动态分布。结果显示，甲状腺摄取９９ｍＴｃ－ＭＩＢＩ高峰在注药后３—６０ｍｉｎ，其前３ｍｉｎ主要与血供有关。１５—６０ｍｉｎ是腺体摄取的主要过程，为浓聚滞留时间，注药后６０ｍｉｎ内单位重量甲状腺组织摄取放射性大于同时间其它脏器和组织。放射自显影结果显示，在甲状腺滤泡细胞周边部即上皮细胞及其周围银颗粒分布致密，而在滤泡腔内的胶质和滤泡间质内很少或基本未见银颗粒。随着时间的推移，银颗粒在滤泡细胞内的分布规律不变，银颗粒的集聚与甲状腺滤泡所处的功能状态相一致。

Abstract

Distribution of 99mTc-MIBI was studied in frozen section of rat thyroid tissue using autoradiography and γ counter detector at different times after cauda vein injection. The results demonstrated that the ability of thyroid to uptake 99mTc-MIBI was strongest at 3 minute after injection and the speed of excretion was slow in the period from 15 to 60 minutes and thus formed the retention period with the highest concentration. 99mTc-MIBI was rapidly eliminated after 60 minutes and autoradiographic film exhibited that large amount of 99mTc-MIBI distributed in follicular epithelial cells especilly in basal part.

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Autoradiographic Observation on distribution of 99mTc-MIBI in rat thyroid

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摘要

Abstract

关键词

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Autoradiographic Observation on distribution of ^99mTc-MIBI in rat thyroid