The studies on radio-protective effects of IL-6 to normal tissue of irradiated tumor bearing mice

LIU Yongbiao MEI Kai LIU Ying HAO Xingzhi ZHAO Jie ZHANG Xianwen ZHOU Qiang YAO Side

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The studies on radio-protective effects of IL-6 to normal tissue of irradiated tumor bearing mice

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- The studies on radio-protective effects of IL-6 to normal tissue of irradiated tumor bearing mice
- NUCLEAR TECHNIQUES Issue 11, (2004)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所
  2. 徐州医学院肿瘤研究所
  3. 中国科学院上海应用物理研究所上海 201800 徐州医学院肿瘤研究所,徐州,221002
- 作者简介：
- 基金信息：
- DOI：
  CLC： R73-3
- Published：01 November 2004
- 稿件说明：
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[1]刘永彪,梅开,刘颖,郝兴芝,赵杰,张先稳,周强,姚思德.白细胞介素-6对荷瘤小鼠正常组织的辐射保护效应[J].核技术,2004(11):843-847.

LIU Yongbiao MEI Kai LIU Ying HAO Xingzhi ZHAO Jie ZHANG Xianwen ZHOU Qiang YAO Side. The studies on radio-protective effects of IL-6 to normal tissue of irradiated tumor bearing mice[J]. Nuclear techniques, 2004, (11): 843-847.
[1]刘永彪,梅开,刘颖,郝兴芝,赵杰,张先稳,周强,姚思德.白细胞介素-6对荷瘤小鼠正常组织的辐射保护效应[J].核技术,2004(11):843-847. DOI：

LIU Yongbiao MEI Kai LIU Ying HAO Xingzhi ZHAO Jie ZHANG Xianwen ZHOU Qiang YAO Side. The studies on radio-protective effects of IL-6 to normal tissue of irradiated tumor bearing mice[J]. Nuclear techniques, 2004, (11): 843-847. DOI：

摘要

以受全身照射的S180肉瘤荷瘤小鼠为研究对象

利用化学比色法测定荷瘤鼠肝脏、脾脏、肾脏、心脏、肺、脑和骨髓组织的活性氧（ROS）、丙二醛（MDA）水平和谷胱苷肽过氧化物酶（GSH-Px）、过氧化氢酶（CAT）活性

探讨白细胞介素-6（IL-6）对荷瘤机体正常组织辐射防护效应及机理。结果显示:荷瘤鼠受照射后其肝脏、肾脏、脾脏、骨髓、脑、肺组织匀浆中ROS、MDA含量明显升高

而GSH-Px和CAT活性明显降低

其机制是电离辐射造成抗氧化酶的损伤及机体内自由基含量上升。IL-6能够显著降低受照射荷瘤小鼠肝脏、脾脏、骨髓、脑组织匀浆中活性氧（ROS）、丙二醛（MDA）水平

提高谷胱苷肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）活性。对肾脏、肺组织匀浆中ROS、MDA含量和GSH-Px、CAT活性无明显影响。本实验提示IL-6通过清除ROS和保护抗氧化酶的损伤起辐射保护作用

IL-6对不同组织细胞辐射保护作用程度不同

是由于机体细胞中IL-6R的数量、亲和力及IL-6信号传导途径存在差异。

Abstract

In order to investigate radioprotective effects of interleukin-6 (IL-6) to normal tissues of irradiated tumor-bearing S180 sarcoma mice and its related mechanism

the contents of reactive oxygen species(ROS)

malondialdehyde (MDA)

activity of glutathione peroxidaes (GSH-Px) and catalase (CAT) in liver

kidney

spleen

lung

brain

marrow were determined. It was found that the content of ROS and MDA increased and the content of GSH-Px and CAT decreased in normal tissues of tumor-bearing S180 sarcoma mice under fractional total-body-irradiation (TB1). With addition of IL-6 the content of ROS and MDA was decreased and the activity of GSH-Px and CAT was increased in liver

spleen

brain

marrow

whereas there is no significant effect on the lung and kidney tissues. It can be deduced that IL-6 has some radio-protective effects to the normal tissue of tumor-bearing mice involved in fractional TBI via scavenging ROS and protecting antioxidant enzymes. As the number

affinity of IL-6 receptor and signal transfer pathway of IL-6 are changeable

the radio-protective effects of IL-6 in various tissues are different.

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