Preparation and experimental study of infection imaging agent (99)~Tc~m-LVFX

YUAN Zhibin

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Preparation and experimental study of infection imaging agent (99)~Tc~m-LVFX

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- Preparation and experimental study of infection imaging agent (99)~Tc~m-LVFX
- NUCLEAR TECHNIQUES Issue 11, (2004)
- 作者机构：
  
  1. 上海交通大学附属第六人民医院
  2. 日本群马大学医学部
  4. 核医学,日本,371-8511
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817.5
- Published：01 November 2004
- 稿件说明：
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[1]袁志斌,Keiko KOYAMA,Tetsuya HIGUCHI,Noboru ORIUCHI,Keigo ENDO.炎症显像剂~(99)Tc~m-LVFX的标记与动物实验研究[J].核技术,2004(11):858-860.

YUAN Zhibin. Preparation and experimental study of infection imaging agent (99)~Tc~m-LVFX[J]. Nuclear techniques, 2004, (11): 858-860.
[1]袁志斌,Keiko KOYAMA,Tetsuya HIGUCHI,Noboru ORIUCHI,Keigo ENDO.炎症显像剂~(99)Tc~m-LVFX的标记与动物实验研究[J].核技术,2004(11):858-860. DOI：

YUAN Zhibin. Preparation and experimental study of infection imaging agent (99)~Tc~m-LVFX[J]. Nuclear techniques, 2004, (11): 858-860. DOI：

摘要

核医学影像检查对炎症疾病的诊断有独特的价值

标记抗生素是近来新开发的一类炎症显像剂。本文用Tc标记了左旋氧氟沙星（LVFX）

研究其生物分布和动物模型的显像结果。使用酒石酸亚锡作为还原剂

快速标记LVFX。研究了99Tcm-LVFX在炎症动物模型内的生物分布和炎症动物模型注射99Tcm-LVFX后的显像结果。结果表明标记方法简单迅速

标记物稳定。生物分布和显像结果均表明99Tcm-LVFX在炎症组织内有较高的摄取。研究提示99Tcm-LVFX是一种潜在的炎症显像剂。

Abstract

Radionuclide scintigraphy has its unique value for the diagnosis of inflammatory diseases. The recently developed labeled antibiotics is a new kind of imaging agents in this field. The aim of this paper is to radio label the LVFX with 99Tcm and stannous tartrate as reducing agent The biodistribution of 99Tcm-LVFX in animal model and whole body scintigraphy of animal model were fulfilled. The results showed that labeling method was easy and fast

labelled agent was stable. Both biosdistribution and imaging result showed higher uptake of 99Tcm-LVFX in infection site. It is suggested that technetium labeled LVFX is a potential infection imaging agent.

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Related Author

YUAN Zhibin1 Katsumi TOMIYOSHI2 Tetsuya HIGUCHI2 Noboru ORIUCHI2 Keigo ENDO2 1

Katsumi TOMIYOSHI

Tetsuya HIGUCHI

Noboru ORIUCHI

Keigo ENDO

王自正

阮长耿

王峰

Related Institution

Shanghai 6th People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233) 2

日本群马大学医学部核医学

Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China) 2

苏州大学附属第一医院江苏省血液研究所

南京医科大学附属南京第一医院核医学科

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