Hypoxic imaging of cerebral ischaemia using with (99)~Tc~m-HL91 in animal experimental and clinical study

JIANG Ningyi LIU Sheng ZHU Cansheng WANG Yidong XING Yigang

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Hypoxic imaging of cerebral ischaemia using with (99)~Tc~m-HL91 in animal experimental and clinical study

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- Hypoxic imaging of cerebral ischaemia using with (99)~Tc~m-HL91 in animal experimental and clinical study
- NUCLEAR TECHNIQUES Issue 11, (2004)
- 作者机构：
  
  1. 中山大学第二附属医院
  2. 中山大学第二附属医院,广州,510120
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817
- Published：01 November 2004
- 稿件说明：
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[1]蒋宁一,刘生,朱灿胜,王艺东,邢诒刚.~(99)Tc~m-HL91乏氧显像脑缺血动物实验与初步临床研究[J].核技术,2004(11):833-837.

JIANG Ningyi LIU Sheng ZHU Cansheng WANG Yidong XING Yigang. Hypoxic imaging of cerebral ischaemia using with (99)~Tc~m-HL91 in animal experimental and clinical study[J]. Nuclear techniques, 2004, (11): 833-837.
[1]蒋宁一,刘生,朱灿胜,王艺东,邢诒刚.~(99)Tc~m-HL91乏氧显像脑缺血动物实验与初步临床研究[J].核技术,2004(11):833-837. DOI：

JIANG Ningyi LIU Sheng ZHU Cansheng WANG Yidong XING Yigang. Hypoxic imaging of cerebral ischaemia using with (99)~Tc~m-HL91 in animal experimental and clinical study[J]. Nuclear techniques, 2004, (11): 833-837. DOI：

摘要

乏氧显像是近年来核医学显像的一种新技术。研究表明乏氧组织与正常组织的摄取比明显提高

可用于病灶组织缺血缺氧的判断。99Tcm-HL91作为一种新型乏氧组织显像剂能够选择性地滞留于缺血部位的脑组织中

通过SPECT显像可为脑缺血性疾病提供诊断信息。本研究通过脑缺血动物模型

探讨99Tcm-HL91在局部脑缺血模型脑组织中的分布特点

应用放射性自显影技术对局部脑缺血模型进行脑组织宏观放射性自显影研究。同时对21例急性脑梗塞患者进行了初步99Tcm-HL91脑显像观察。

Abstract

The objective is to explore the distribution of 99Tcm-HL91 in cerebral ischaemia animal model and evaluate the 99Tcm-HL91 cerebral ischaemia imaging clinicaly. After animal models were established

99Tcm-HL91 biodistribution was studied by autoradiography. Also

21 patients who suffered from acute cerebral infarction within 96 hours were studied by 99Tcm-HL91 cerebral imaging. Experimental results show that in the ischemic territory more 99Tcm-HL91 accumulated than in the opposite site by autoradiogram. Using computer-enhanced imaging analysis

the optical density (OD) ratio between target and non-target site was significant. In clinical study

8 patients had positive imaging showing accumulation of 99Tcm-HL91 in the surrounding of infarction site. It is concluded that 99Tcm-HL91 can be avidly taken up by cerebral ischemic tissue. 99Tcm-HL91 is a potential agent for imaging hypoxic tissue

and SPECT imaging can be used to evaluate cerebral ischaemia.

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