Recent progress in application of MAG3 labeling radio-metals

ZHANG Xiuli WANG Yongxian YIN Duanzhi LI Junling CAO Jinquan

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Recent progress in application of MAG3 labeling radio-metals

更新时间：2021-03-12

- Recent progress in application of MAG3 labeling radio-metals
- NUCLEAR TECHNIQUES Issue 2, (2004)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所
  2. 中国科学院上海应用物理研究所,上海,201800
- 作者简介：
- 基金信息：
  
  中国科学院创新工程重大项目(KJCX1-SW-08)资助
- DOI：
  CLC： R817
- Published：01 February 2004
- 稿件说明：
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[1]张秀利,汪勇先,尹端沚,李俊玲,曹金全.MAG_3在放射性金属标记应用中的最新研究进展[J].核技术,2004(02):133-137.

ZHANG Xiuli WANG Yongxian YIN Duanzhi LI Junling CAO Jinquan. Recent progress in application of MAG3 labeling radio-metals[J]. Nuclear techniques, 2004, (2): 133-137.
[1]张秀利,汪勇先,尹端沚,李俊玲,曹金全.MAG_3在放射性金属标记应用中的最新研究进展[J].核技术,2004(02):133-137. DOI：

ZHANG Xiuli WANG Yongxian YIN Duanzhi LI Junling CAO Jinquan. Recent progress in application of MAG3 labeling radio-metals[J]. Nuclear techniques, 2004, (2): 133-137. DOI：

摘要

综述了利用巯乙酰基三甘氨酸（MAG3）标记的多肽的生物学特性。经 MAG3形成的 Tcm标记物的标 99记率和比放射性高，体内稳定性好，与血清蛋白的非特异性结合低；经 MAG3 形成的186/188Re 标记物也具有良好的体内外稳定性。

Abstract

The biological behaviors of the labeling conjugates with MAG3 were summarized. The 99Tcm labeling conjugates by using MAG3 show high labeling efficiencies and high specific activities and hold desirable stability in vitro and in vivo. The binding of the labeling conjugates with plasma protein is low; the 186/188Re labeling compounds

using MAG3 as BFCA

also hold desirable stability in vitro and in vivo. So many potentially useful biomolecules labeled by 99Tcm

186/188Re for diagnosis and therapy may be produced via MAG3.

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